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Recombinant Human Glutathione S-Transferase Mu 2 (Muscle), His-tagged

Cat. No.: GSTM2-1691H
Product Overview: Recombinant human GSTM2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques
Description: GSTM2, also known as Glutathione S-transferase Mu 2, is a member of the glutathione s-transferase (GST) family of proteins. There are eight families of GST proteins, namely alpha, kappa, mu, omega, pi, sigma, theta and zeta, each of which is composed of proteins that have a variety of functions throughout the cell. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.
Concentration: 0.5 mg/ml
Source: Human
Host: E.coli
Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 0.1M NaCl and 1mM DTT.
Purity: > 95% by SDS - PAGE
Sequence: 1-218 amino acids: MGSSHHHHHH SSGLVPRGSH MPMTLGYWNI RGLAHSIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGTHKI TQSNAILRYI ARKHNLCGES EKEQIREDIL ENQFMDSRMQ LAKLCYDPDF EKLKPEYLQA LPEMLKLYSQ FLGKQPWFLG DKITFVDFIA YDVLERNQVF EPSCLDAFPN LKDFISRFEG LEKIS
Molecular Mass: 27.9 kDa (238aa), confirmed by MALDI-TOF
Applications: SDS-PAGE
Bioactivity: Specific activity is < 25 units/mg, and is defined as the amount of enzyme that conjugate 1.0 uM of 1-chloro-2,4-dinitrobenzene (CDNB) with reduced glutathione per minute at pH 6.5 at 25 DEG C.
Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name: GSTM2 glutathione S-transferase mu 2 (muscle) [ Homo sapiens ]
Official Symbol: GSTM2
Synonyms: GSTM2; glutathione S-transferase mu 2 (muscle); GST4; GSTM; GTHMUS; GSTM2-2; MGC117303; glutathione S-transferase Mu 2; GST, muscle; GST class-mu 2; OTTHUMP00000013350; OTTHUMP00000013353; glutathione S-transferase 4; glutathione S-transferase M1; glutathione S-aryltransferase M2; glutathione S-alkyltransferase M2; glutathione S-aralkyltransferase M2; S-(hydroxyalkyl)glutathione lyase M2; EC 2.5.1.18; glutathione S-transferase M2 (muscle)
Gene ID: 2946
mRNA Refseq: NM_000848
Protein Refseq: NP_000839
MIM: 138380
UniProt ID: P28161
Chromosome Location: 1p13.3
Pathway: Drug metabolism - cytochrome P450; Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450
Function: glutathione transferase activity; transferase activity

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