"IGFBP6" Related Products

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Recombinant Human IGFBP6 protein

Cat.No.: IGFBP6-5053H
Product Overview: Recombinant Human IGFBP6 was expressed in Insect cells.
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6 is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid, and specifically inhibits IGF-II actions. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma.
Source: Insect cells
Species: Human
Bio-activity: Determined by its ability to inhibit IGF-II induced proliferation of human MCF-7 cells. The expected ED50 for this effect is 0.1 – 0.4 μg/ml.
Molecular Mass: Recombinant human IGF-BP6 has a calculated mass of 22.6 kDa and consists of 213 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE analysis under non-reducing conditions.
AA Sequence: RCPGCGQGV QAGCPGGCV EEEDGGSPA EGCAEAEGC LRREGQECG VYTPNCAPG LQCHPPKDD EAPLRALLL GRGRCLPAR APAVAEENP KESKPQAGT ARPQDVNRR DQQRNPGTS TTPSQPNSA GVQDTEMGP CRRHLDSVL QQLQTEVYR GAQTLYVPN CDHRGFYRK RQCRSSQGQ RRGPCWCVD RMGKSLPGS PDGNGSSSC PTGSSG
Purity: Above 95% as determined by SDS-PAGE Analysis.
Gene Name: IGFBP6 insulin-like growth factor binding protein 6 [ Homo sapiens ]
Official Symbol: IGFBP6
Synonyms: IGFBP6; insulin-like growth factor binding protein 6; insulin-like growth factor-binding protein 6; IBP-6; IGFBP-6; IGF binding protein 6; IGF-binding protein 6; IBP6;
Gene ID: 3489
mRNA Refseq: NM_002178
Protein Refseq: NP_002169
MIM: 146735
UniProt ID: P24592

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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