Active Recombinant Human IGFBP6 protein

• Cat.No.: IGFBP6-5053H
• Product Overview: Recombinant Human IGFBP6 was expressed in Insect cells.

Specification

• Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6 is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid, and specifically inhibits IGF-II actions. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma.
• Source: Insect cells
• Species: Human
• Bio-activity: Determined by its ability to inhibit IGF-II induced proliferation of human MCF-7 cells. The expected ED50 for this effect is 0.1 – 0.4 μg/ml.
• Molecular Mass: Recombinant human IGF-BP6 has a calculated mass of 22.6 kDa and consists of 213 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE analysis under non-reducing conditions.
• AA Sequence: RCPGCGQGV QAGCPGGCV EEEDGGSPA EGCAEAEGC LRREGQECG VYTPNCAPG LQCHPPKDD EAPLRALLL GRGRCLPAR APAVAEENP KESKPQAGT ARPQDVNRR DQQRNPGTS TTPSQPNSA GVQDTEMGP CRRHLDSVL QQLQTEVYR GAQTLYVPN CDHRGFYRK RQCRSSQGQ RRGPCWCVD RMGKSLPGS PDGNGSSSC PTGSSG
• Purity: Above 95% as determined by SDS-PAGE Analysis.

Gene Information

• Gene Name: IGFBP6 insulin-like growth factor binding protein 6 [ Homo sapiens ]
• Official Symbol: IGFBP6
• Synonyms: IGFBP6; insulin-like growth factor binding protein 6; insulin-like growth factor-binding protein 6; IBP-6; IGFBP-6; IGF binding protein 6; IGF-binding protein 6; IBP6
• Gene ID: 3489
• mRNA Refseq: NM_002178
• Protein Refseq: NP_002169
• MIM: 146735
• UniProt ID: P24592