"MMP2" Related Products

Recombinant Human Matrix Metallopeptidase 2 (Gelatinase A, 72 KDa Gelatinase, 72 KDa Type IV Collagenase)

Cat. No.: MMP2-1715H
Product Overview: Recombinant human MMP2 was expressed in E. coli and purified by SDS PAGE and HPLC, 62.0 KDa.
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens.
Source: Human
Host: E.coli
Form: Supplied as a lyophilized powder.
Purity: > 90% pure by SDS PAGE and HPLC
Sequence: Region of MMP2 protein corresponding to amino acids MYNFFPRKPK WDKNQITYRI IGYTPDLDPE TVDDAFARAF QVWSDVTPLR FSRIHDGEAD IMINFGRWEH GDGYPFDGKD GLLAHAFAPG TGVGGDSHFD DDELWTLGEG QVVRVKYGNA DGEYCKFPFL FNGKEYNSCT DTGRSDGFLW CSTTYNFEKD GKYGFCPHEA LFTMGGNAEG QPCKF
Molecular Mass: 62.0 kDa
Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Bioactivity: MMP-2 activity was measured by its ability to cleave a chromogenic peptide MMP-2 substrate at room temperature. At an MMP-2 concentration of 2.5 ug/ml, 50% cleavage was achieved at an incubation time of approximately 25 minutes.
Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name: MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [ Homo sapiens ]
Official Symbol: MMP2
Synonyms: MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); MONA; CLG4A; TBE-1; MMP-II; matrix metalloproteinase 2; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-II; CLG4; EC 3.4.24.24; Matrix metalloproteinase-2; MMP-2; Gelatinase A
Gene ID: 4313
mRNA Refseq: NM_001127891
Protein Refseq: NP_001121363
MIM: 120360
UniProt ID: P08253
Chromosome Location: 16q13-q21
Pathway: ATF-2 transcription factor network; Angiopoietin receptor Tie2-mediated signaling; Bladder cancer; Diabetes pathways; GnRH signaling pathway; IL-3 Signaling Pathway; LPA receptor mediated events; Leukocyte transendothelial migration; Matrix Metalloproteinases; Osteopontin-mediated events; Pathways in cancer; Plasma membrane estrogen receptor signaling
Function: metal ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding

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