"IL17F" Related Products

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Recombinant Human Interleukin 17F

Cat. No.: IL17F-36H
Product Overview: Recombinant Human IL-17F produced inE. coliis a disulfide-linked homodimer of 30.1 kDa, consisting of two 134 amino acid residue non-glycosylated polypeptide chains.
Description: IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice.Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.
Purity: Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Formulation: Lyophilized from a concentrated (1mg/ml) solution containing 20mM phosphate buffer at pH7.4.
Specific Activity: The ED50 as determined by the dose-dependent induction of IL-6 in NIH-3T3 cells was found to be approximately 10ng/ml, corresponding to a Specific Activity of 1.0 x 105IU/mg.
Endotoxin: Less than 0.1ng/μg (1 IEU/μg) of rHuIL-17F.
Reconstitution: It is recommended to reconstitute the lyophilized rHuIL-17F in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Storage: Lyophilized rHuIL-17F although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. For laboratory in vitro research use only.
Gene Name: IL17F interleukin 17F [ Homo sapiens ]
Synonyms: interleukin17F; ML1; ML-1; IL-17F; IL17F; interleukin17F; cytokine ML-1; IL-24; IL24; Interleukin-24.
Gene ID: 112744
mRNA Refseq: NM_052872
Protein Refseq: NP_443104
MIM: 606496
UniProt ID: Q96PD4
Chromosome Location: 6p12
Function: cytokine activity; cytokine binding; protein homodimerization activity

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