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Recombinant Human Pigment Epithelium-derived Factor

Cat. No.: SERPINF1-07H
Product Overview: Recombinant Human Pigment Epithelium-derived Factor produced in E.coli is a single non-glycosylated polypeptide chain containing 400 amino acids and having a molecular mass of approximately 44.5KDa.
Description: PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member.
Purity: >95% by SDS-PAGE and HPLC analyses.
Formulation: Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH7.4, 150mM NaCl.
Endotoxin: Less than 1EU/mg of rHuPEDF as determined by LAL method
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at<-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage: This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name: SERPINF1
Synonyms: EPC-1, PEDF, PIG35, Serpin-F1; pigment epithelium-derived factor; proliferation-inducing protein 35; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Pigment epithelium-derived factor precursor; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; SERPINF1
Gene ID: 5176
mRNA Refseq: NM_002615
Protein Refseq: NP_002606
MIM: 172860
UniProt ID: P36955
Chromosome Location: 17p13.1
Function: serine-type endopeptidase inhibitor activity

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