"IGF1R" Related Products

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Recombinant Human Insulin-like Growth Factor 1 Receptor, His-tagged

Cat. No. : IGF1R-29H
Description : IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits. Both the α and β subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The α subunit of IGF-I receptor is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. A DNA sequence encoding the extracellular domain of human IGF-I receptor pre-propeptide (amino acid residues Met 1 - Asn 932) with ten histidine residues added at the carboxy terminus was expressed in HEK293 cell line.
Amino-Acid Sequence : 932aa. glycosylated
M. W. : 108 kDa
Recombinant : Expressed in HEK293
Purity : > 90%, as determined by SDS-PAGE and visualized by silver stain.
Formulation : Lyophilized from a 0.2 μm filtered solution in PBS containing 5% trehalose
Endotoxin : < 1.0 EU per 1 μg of the protein as determined by the LAL method.
Reconstitution : It is recommended that sterile PBS be added to the vial to prepare a working stock solution of no less than 100 μg/mL.
Storage : Lyophilized samples are stable for up to twelve months from date of receipt at -20° C to -70° C. Upon reconstitution, this cytokine can be stored under sterile conditions at -20° C to -70° C in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Gene Name : IGF1R
Synonyms : CD221; IGFIR; JTK13; MGC18216; EC 2.7.10.1; MGC142170; MGC142172; CD221 antigen; IGF-I receptor; Insulin-like growth factor I receptor; insulin-like growth factor 1 receptor
Gene ID : 3480
mRNA Refseq : NM_000875.3
Protein Refseq : NP_000866.1
MIM : 147370
UniProt ID : P08069
Chromosome Location : 15q26.3
Pathway : Adherens junction ;Colorectal cancer ;Focal adhesion; Glioma;Long-term depression; Melanoma; Prostate cancer
Function : ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor receptor binding; nucleotide binding; phosphoinositide 3-kinase binding.

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