"CCL17" Related Products

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Recombinant Human Chemokine (C-C Motif) Ligand 17

Cat. No.: CCL17-24H
Product Overview: Recombinant Human CCL17 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 71 amino acids and having a molecular mass of 8 kDa. The TARC is purified by proprietary chromatographic techniques.
Description: Along with CC chemokine family members, CCL-17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1α, MIP-1β, MCP-1, MCP-2, MCP-3 and I-309. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
Source: Escherichia Coli.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: The protein was lyophilized from a concentrated (0.5 mg/ml) solution containing 20 mM PBS & 150 mM NaCl pH 7.4.
Solubility: It is recommended to reconstitute the lyophilized CCL17 in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Specific Activity: Determined by its ability to chemoattract human T-Lymphocytes using a concentration range of 1.0-10.0 ng/ml.
Stability: Lyophilized TARC although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TARC should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Pathways: Cytokine-cytokine receptor interaction
Gene Name: CCL17 chemokine (C-C motif) ligand 17 [ Homo sapiens ]
Synonyms: chemokine (C-C motif) ligand 17; TARC; ABCD-2; SCYA17; A-152E5.3; MGC138271; MGC138273; CCL17; small inducible cytokine A17; T cell-directed CC chemokine; thymus and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 17; CC chemokine TARC; OTTHUMP00000164673
Gene ID: 6361
mRNA Refseq: NM_002987
Protein Refseq: NP_002978
MIM: 601520
UniProt ID: Q92583
Chromosome Location: 16q13
Function: chemokine activity

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