Recombinant Human Chemokine (C-X-C Motif) Ligand 10, His-tagged CXCL10-32H

Recombinant Human Chemokine (C-X-C Motif) Ligand 10, His-tagged

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Recombinant Human Chemokine (C-X-C Motif) Ligand 10, His-tagged

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Cat.No. : CXCL10-32H
Product Overview : Recombinant Human IP-10 His Tag produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 77 amino acids fragment (22-98) and having a total molecular mass of 8.5 kDa with an amino-terminal hexahistidine tag. The IP-10 His is purified by proprietary chromatographic techniques.
Description : Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein (γ-IP10 or IP-10). CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.
Source : E.Coli
Species : Human
Tag : His
Form : Sterile Filtered clear solution. CXCL10-10 His is supplied in 10mM Tris HCl pH8, 1mM EDTA and 50% glycerol.
Molecular Mass : 8.5 kDa
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC; (b) Analysis by SDS-PAGE.
Applications : Purified progelatinase B monomer can serve as antigen standard in immunochemical analyses. Active gelatinase B is used to study the degradation of extracellular matrix proteins, to screen inhibitors of matrix metalloproteinases and to characterize inhibitor actions.
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name : MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) [ Homo sapiens (human) ]
Official Symbol : MMP9
Synonyms : MMP9; GELB; CLG4B; MMP-9; MANDP2; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase-9; 92 kDa gelatinase; type V collagenase; macrophage gelatinase; 92 kDa type IV collagenase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); EC 3.4.24.35
Gene ID : 4318
mRNA Refseq : NM_004994
Protein Refseq : NP_004985
MIM : 120361
UniProt ID : P14780
Chromosome Location : 20q11.2-q13.1
Pathway : AGE/RAGE pathway; Activation of Matrix Metalloproteinases; Angiogenesis
Function : collagen binding; metalloendopeptidase activity; protein binding

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