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Recombinant Human MSTN, His-tagged

Cat.No. : MSTN-119H
Product Overview : Recombinant Human MSTN(total 152AA.), fused with N-terminal His-tag, was expressed in E.Coli.
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Description : The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
Source : E.Coli
Species : Human
Tag : His
Form : Filtered white lyophilized (freeze-dried) powder. Filtered (0.4µm) and lyophilized from 0.5 mg/ml in 0.05M acetate buffer, pH 4.5.
Molecular Mass : 16.7kDa (calculated)
AA Sequence : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDPSSRSAVR SRRDFGLDCD EHSTESRCCR YPLTVDFEAFGWDWIIAPKR YKANYCSGEC EFVFLQKYPH THLVHQANPR GSAGPCCTPT KMSPINMLYF NGKEQIIYGKIPAMVVDRCG CS.
Purity : Greater than 95% as determined by SDS-PAGE.
Stability : Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Concentration : Add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10μg/ml. In higher concentrations the solubility of this antigen is limited.
Gene Name : MSTN myostatin [ Homo sapiens (human) ]
Official Symbol : MSTN
Synonyms : MSTN; myostatin; GDF8; MSLHP; growth/differentiation factor 8; GDF-8; growth differentiation factor 8
Gene ID : 2660
mRNA Refseq : NM_005259
Protein Refseq : NP_005250
MIM : 601788
UniProt ID : O14793
Chromosome Location : 2q32.2
Pathway : Hypertrophy Model
Function : cytokine activity; growth factor ; heparin binding; identical protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How do MSTN inhibitors work in the context of muscle-related disorders? 03/18/2023

MSTN inhibitors work by blocking the activity of the MSTN protein, thus promoting muscle growth and potentially reversing muscle loss.

Are there any known side effects of using MSTN inhibitors in clinical trials? 02/09/2022

Some potential side effects include joint stiffness, increased risk of fractures, and insulin resistance, which require close monitoring during trials.

How does the overexpression of MSTN affect muscle development? 12/26/2020

Overexpression of MSTN can lead to muscle atrophy and decreased muscle mass.

How do researchers regulate the dosage of MSTN protein therapy to ensure safety and efficacy? 02/07/2020

Researchers carefully monitor the dosage and administration of MSTN protein therapy through preclinical and clinical studies to establish the optimal therapeutic dose.

What are the potential risks associated with MSTN protein therapy? 09/13/2016

Possible risks include unintended effects on other organ systems and potential complications related to excessive muscle growth.

Customer Reviews (3)

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Reviews
04/04/2021

    The MSTN protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.

    11/15/2020

      the manufacturer of MSTN provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.

      02/01/2020

        The outstanding level of customer service adds extra reassurance and confidence in using the MSTN protein for my scientific investigations.

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