"PRL" Related Products

Recombinant Human Prolactin

Cat. No. : PRL-56H
Product Overview : Recombinant Human Prolactin produced inE.Coliis a single, non-glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 23007 Dalton. The Prolactin is purified by proprietary chromatographic techniques.
Description : Prolactin is a neuroendocrine hormone synthesized primarily by the pituitary gland but also a variety of other cell types including the placenta, brain and uterus. Its primary function is to promote and maintain lactation but has also been shown to have a role in breast cancer development, regulation of reproductive function and immunoregulation.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : The protein was lyophilized from a concentrated (1 mg/ml) solution with 10 mM sodium Phosphate buffer pH=8 and 50 mM Nacl.
Solubility : It is recommended to reconstitute the lyophilized Prolactin in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Amino Acid Sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Pro-Ile-Cys.
Biological Activity : The ED50as determined by the dose-dependant stimulation of the proliferation of rat lymphoma, Nb2-11 was found to be < 0.065 ng/ml.
Storage : Lyophilized Prolactin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Prolactin should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : PRL prolactin [ Homo sapiens ]
Synonyms : PRL; prolactin; OTTHUMP00000017727
Gene ID : 5617
mRNA Refseq : NM_000948
Protein Refseq : NP_000939
MIM : 176760
UniProt ID : P01236
Chromosome Location : 6p22.2-p21.3
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Neuroactive ligand-receptor interaction
Function : hormone activity; prolactin receptor binding

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