Native Human Placental Alkaline Phosphatase
Cat.No. : | ALPP-8005H |
Product Overview : | Human Placental Alkaline Phosphatase was purified from Human Placenta. |
- Specification
- Gene Information
- Related Products
Description : | In human(s), alkaline phosphatase is present in all tissues throughout the entire body, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta. The optimal pH for the enzyme activity is pH 10 in standard conditions.One unit will convert one micromole of p-nitrophenyl phosphate to p-nitrophenol and phosphate per minute at 37 oC in the presence of AMP (2-amino-2-methyl-1-propanol) at pH 10.35. |
Source : | Human Placenta |
Species : | Human |
Form : | Lyophilized |
Purity : | >98% by SDS-PAGE |
Stability : | 1 Year |
Storage : | -20 °C |
Concentration : | Typically >0.01 mg protein/mg |
Gene Name : | ALPP alkaline phosphatase, placental [ Homo sapiens ] |
Official Symbol : | ALPP |
Synonyms : | ALPP; alkaline phosphatase, placental; alkaline phosphatase, placental (Regan isozyme); alkaline phosphatase, placental type; Regan isozyme; PLAP-1; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase R |
Gene ID : | 250 |
mRNA Refseq : | NM_001632 |
Protein Refseq : | NP_001623 |
MIM : | 171800 |
UniProt ID : | P05187 |
Chromosome Location : | 2q37.1 |
Pathway : | Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; |
Function : | alkaline phosphatase activity; alkaline phosphatase activity; hydrolase activity; metal ion binding; |
Products Types
◆ Recombinant Protein | ||
ALPP-2558H | Recombinant Human ALPP protein(31-500 aa), C-His-tagged | +Inquiry |
ALPP-302H | Recombinant Human ALPP Protein, His tagged | +Inquiry |
ALPP-329H | Recombinant Human ALPP Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPP-125H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-124H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
ALPP-8347H | Native Human ALPP | +Inquiry |
◆ Lysates | ||
ALPP-8893HCL | Recombinant Human ALPP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.
ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.
ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.
ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.
ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.
ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.
ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.
Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.
ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.
ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.
Customer Reviews (3)
Write a reviewHigh-throughput screening compatibility.
Consistent protein expression analysis.
Precise protein quantification in ELISA.
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