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Active Recombinant Mouse Osm

Cat.No. : Osm-8302M
Product Overview : Recombinant Mouse Osm was expressed in E. coli.
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  • Gene Information
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Description : Oncostatin M (OSM) is a pleitropic cytokine produced by activated T lymphocytes and monocytes that is structurally and functionally related to the subfamily of cytokines known as the IL-6-type cytokine family.?OSM either inhibits or enhances the growth of cells depending on cell type. It inhibits proliferation of skeletal muscle cells by blocking cell cycle progression from G(1) to S phase.?OSM is also a key mediator for proliferation and anti-apoptosis of hepatocytes which suggests that OSM gene therapy is useful, as preventive and curative means, for the treatment of patients with liver damage.
Source : E. coli
Species : Mouse
Form : This recombinant protein was 0.2 μm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Bio-activity : The biological activity of Mouse OSM was measured in a cell proliferation assay using NIH/3T3 mouse embryonic fibroblasts. The expected ED50= 0.25-1.0 ng/ml.
Molecular Mass : The predicted molecular weight of Recombinant Mouse OSM is Mr 21 kDa.
AA Sequence : manrgcsn sssqllsqlq nqanltgnte sllepyirlq nlntpdlraa ctqhsvafps edtlrqlskp hflstvyttl drvlyqldal rqkflktpaf pkldsarhni lgirnnvfcm arllnhslei peptqtdsga srstttpdvf ntkigscgfl wgyhrfmgsv grvfrewddg strsrr
Endotoxin : <0.1 eu/μg as determined by the lal>
Purity : >97% by SDS-PAGE and analyzed by silver stain.
Storage : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Osm oncostatin M [ Mus musculus ]
Official Symbol : Osm
Synonyms : OSM; oncostatin M; oncostatin-M; OncoM;
Gene ID : 18413
mRNA Refseq : NM_001013365
Protein Refseq : NP_001013383
Pathway : Adipogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : cytokine activity; cytokine activity; growth factor activity; oncostatin-M receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of OSM on cancer development and progression, particularly in terms of tumor microenvironment modulation? 03/25/2022

OSM can influence cancer progression by altering the tumor microenvironment and affecting tumor cell behavior.

How does OSM (Oncostatin M) regulate inflammatory and immune responses in the body? 01/30/2021

OSM plays a key role in regulating inflammatory and immune responses, modulating cytokine production and immune cell activity.

How does OSM contribute to wound healing and tissue regeneration processes? 06/08/2020

OSM aids in wound healing and tissue regeneration, promoting cell growth and repair mechanisms.

What role does OSM play in the pathogenesis of autoimmune diseases like rheumatoid arthritis? 04/27/2020

OSM is implicated in autoimmune diseases, contributing to inflammation and joint damage in conditions like rheumatoid arthritis.

How does OSM influence liver fibrosis and hepatic diseases? 03/17/2020

OSM is involved in liver fibrosis, impacting the development and progression of hepatic diseases.

What are the mechanisms by which OSM modulates cellular growth, differentiation, and apoptosis? 06/22/2018

OSM regulates cellular processes like growth, differentiation, and apoptosis, affecting various tissue functions.

How do alterations in OSM expression or signaling affect cardiovascular health and disease? 02/20/2018

Changes in OSM signaling can impact cardiovascular health, influencing disease development and progression.

Customer Reviews (3)

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Reviews
11/25/2020

    Outstanding protein-protein interaction studies, vital for our projects.

    03/02/2020

      High-quality protein characterization, fundamental for our experiments.

      02/27/2019

        Expertise in peptide synthesis, accelerates our peptide-based research.

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