"GFRA1" Related Products


Recombinant Human GFRA1

Cat.No.: GFRA1-8324H
Product Overview: Recombinant Human GFRA1 was expressed in NSO Cells.
Description: GDNF family receptor alpha 1, also known as GFRA1 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRalpha1 functions as a ligand-induced cell adhesion molecule (LICAM) to establish precise synaptic contacts and induce presynaptic differentiation.
Source: NSO Cells
Species: Human
Form: This recombinant protein was 0.2 μm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Bio-activity: The biological activity of Human GFRα-1 was determined by its ability to bind recombinant human GDNF. Immobilized recombinant human GFRα-1/Fc at 2 μg/ml (100 μl/well) can bind recombinant human GDNF with a linear range at 0.78 - 5 ng/ml in a functional ELISA assay.
Molecular Mass: The predicted molecular weight of Recombinant Human GFRα-1 is Mr 73.3 kDa (monomer). However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 88-95 kDa.
AA Sequence: ae vsggdrldcv kasdqclkeq scstkyrtlr qcvagketnf slasgleakd ecrsamealk qkslyncrck rgmkkekncl riywsmyqsl qgndlledsp yepvnsrlsd ifrvvpfisv ehipkgnncl daakacnldd ickkyrsayi tpcttsvsnd vcnrrkchka lrqffdkvpa khsygmlfcs crdiacterr rqtivpvcsy eerekpncln lqdscktnyi crsrladfft ncqpesrsvs sclkenyadc llaysgligt vmtpnyidss slsvapwcdc snsgndleec lkflnffkdn tclknaiqaf gngsdvtvwq pafpvqttta ttttalrvkn kplgpagsen eipthvlppc anlqaqklks nvsgnthlci sngnyekegl gasshittki egrmdpkscd kthtcppcpa pellggpsvf lfppkpkdtl misrtpevtc vvvdvshedp evkfnwyvdg vevhnaktkp reeqynstyr vvsvltvlhq dwlngkeykc kvsnkalpap iektiskakg qprepqvytl ppsrdeltkn qvsltclvkg fypsdiavew esngqpenny kttppvldsd gsfflysklt vdksrwqqgn vfscsvmhea lhnhytqksl slspgkhhhh hh
Endotoxin: <1.0 eu/μg as determined by the lal>
Purity: >90% by SDS-PAGE and analyzed by silver stain.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: GFRA1 GDNF family receptor alpha 1 [ Homo sapiens ]
Official Symbol: GFRA1
Synonyms: GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; RET ligand 1; GDNFR-alpha-1; GDNF receptor alpha-1; GPI-linked anchor protein; PI-linked cell-surface accessory protein; TGF-beta related neurotrophic factor receptor 1; TGF-beta-related neurotrophic factor receptor 1; Glial cell line-derived neurotrophic factor receptor alpha; GFR-ALPHA-1; FLJ10561; FLJ31546; MGC23045; DKFZp313E1012; DKFZp686J0156;
Gene ID: 2674
mRNA Refseq: NM_001145453
Protein Refseq: NP_001138925
MIM: 601496
UniProt ID: P56159
Chromosome Location: 10q25-q26
Pathway: Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Diurnally regulated genes with circadian orthologs, organism-specific biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem; NCAM1 interactions, organism-specific biosystem; Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem;
Function: glial cell-derived neurotrophic factor receptor activity; integrin binding; receptor activity; receptor binding;

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