"HARS" Related Products


Recombinant Human HARS, His tagged

Cat.No.: HARS-8327H
Product Overview: Histidyl-tRNA Synthetase Human Recombinant produced in baculovirus is a single, glycosylated, polypeptide chain having a molecular mass of 58.3 kDa.The Histidyl-tRNA Synthetase is fused to 6x His Tag and purified by chromatographic techniques.
Description: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene.
Source: Sf9 Insect Cells
Species: Human
Tag: His
Form: The protein solution contains 20 mM HEPES, 250mM sodium chloride 0.1% and 20% Glycerol, (pH 7.5).
Purity: Greater than 90.0% as determined by SDS-PAGE.
Applications: Protein quantitation was carried out by using 0.25 2.0 mg/ml Bradford assay vs. BSA.
Notes: For research use only.
Storage: Lyophilized Histidyl-tRNA Synthetase although stable at 4 ℃ for weeks, should be stored desiccated below -18 ℃. Please prevent freeze/thaw cycles.
Gene Name: HARS histidyl-tRNA synthetase [ Homo sapiens ]
Official Symbol: HARS
Synonyms: HARS; histidyl-tRNA synthetase; histidine--tRNA ligase, cytoplasmic; histidine tRNA ligase 1; cytoplasmic; HisRS; histidine translase; HRS; USH3B; FLJ20491;
Gene ID: 3035
mRNA Refseq: NM_001258040
Protein Refseq: NP_001244969
MIM: 142810
UniProt ID: P12081
Chromosome Location: 5q31.3
Pathway: Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Cytosolic tRNA aminoacylation, organism-specific biosystem; Gene Expression, organism-specific biosystem; tRNA Aminoacylation, organism-specific biosystem;
Function: ATP binding; histidine-tRNA ligase activity; ligase activity; nucleotide binding;

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