"IL24" Related Products


Recombinant Human IL24

Cat.No.: IL24-8452H
Product Overview: Recombinant human Il-24 produced in yeast is a single, glycosylated, polypeptide chain containing 158 amino acids and having a molecular mass of 18 kDa. As a result of glycosilation, the protein migrates at 19.5 kDa on SDS-PAGE.
Description: IL24 is a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. IL-10B encoded can induce apoptosis selectively in various cancer cells. Overexpression IL-24 leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. The glycosylation is essential for activity of IL-24. Functionally, IL-24 has diverse activities. At low concentrations, it induces type I proinflammatory cytokines such as IFN-γ, IL-1β, IL-12 and TNF-α. At high concentration, it is a strong inducer of apoptosis in tumor cells, but not normal cells. mda-7/IL-24 is being hailed as a ‘magic bullet’ for cancer gene therapy.
Source: Sacharomyces Cerevisiae
Species: Human
Form: Sterile filtered and lyophilized from PBS with BSA as a carrier
Bio-activity: Measured by its ability to bind to the cell receptor of Capan-1 cells line resulted in Stat-3 activation. The ED?? for this effect is typically 1.0 ng/ml.
Molecular Mass: 19.5 kDa
Endotoxin: <0.1>
Purity: ≥98% by SDS - PAGE; ≥98% by HPLC
Storage: The lyophilized BCA-1/CXCL13 should be storeddesiccated below 0°C. Reconstituted CXCL13 shouldbe stored at working aliquots at -20°C. Avoidfreeze/thaw cycles.
Reconstitution: Reconstitute in sterile dH?O not less than 100 ug/ml. This solution can then be diluted into other aqueous buffers
Shipping: Blue ice
Gene Name: IL24 interleukin 24 [ Homo sapiens ]
Official Symbol: IL24
Synonyms: IL24; interleukin 24; ST16; interleukin-24; C49A; FISP; IL 4 induced secreted protein; IL 24; IL10B; mda 7; melanoma differentiation association protein 7; Mob 5; suppression of tumorigenicity 16 (melanoma differentiation); melanocyte-associated Mda-7; IL-4-induced secreted protein; melanoma differentiation-associated gene 7 protein; MDA7; MOB5;
Gene ID: 11009
mRNA Refseq: NM_001185156
Protein Refseq: NP_001172085
MIM: 604136
UniProt ID: Q13007
Chromosome Location: 1q32
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Senescence and Autophagy, organism-specific biosystem;
Function: cytokine activity;

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