Active Recombinant Human POLR2C, His-tagged
Cat.No. : | POLR2C-8462H |
Product Overview : | Recombinant Human POLR2C, fused with His tag, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | hRPB3 (p33) is a highly conserved subunit shared by all three RNA polymerases. It has been shown to be in close contact to promoter DNA when pol II is recruited into the preinitiation complex . RPB3 has also been implicated in direct protein-protein contacts with transcription factor IIB , Rap30 subunit of transcription factor IIF , and gene-specific modulator proteins, such as the hepatitis B virus transactivator protein X or an inhibitor of pol II, RMP (RPB3-mediating protein). Therefore, RPB3 is facilitating the communication between the pol II core and a variety of basal and gene-specific transcription factors. In the pol II complex, RPB3 interacts with RPB5 and the RPB3–RPB5 interaction is intensified in the presence of three subunits, RPB7, RPB8 and RPB11 . RPB3 also makes direct contacts with both RPB1 and RPB2, the two large subunits of the polymerase complex. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA |
Bio-activity : | 1 unit equals 1 ng of purified protein. 100 units are sufficient for a protein-protein interaction assay. |
AA Sequence : | MPYANQPTVR ITELTDENVK FIIENTDLAV ANSIRRVFIA EVPIIAIDWV QIDANSSVLH DEFIAHRLGL IPLISDDIVD KLQYSRDCTC EEFCPECSVE FTLDVRCNED QTRHVTSRDL ISNSPRVIPV TSRNRDNDPN DYVEQDDILI VKLRKGQELR LRAYAKKGFG KEHAKWNPTA GVAFEYDPDN ALRHTVYPKP EEWPKSEYSE LDEDESQAPY DPNGKPERFY YNVESCGSLR PETIVLSALS GLKKKLSDLQ TQLSHEIQSD VLTIN |
Purity : | >95% as determined by SDS-PAGE |
Storage : | -80 °C |
Concentration : | 350 μg/ml |
Shipping : | Dry Ice |
Gene Name : | POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa [ Homo sapiens ] |
Official Symbol : | POLR2C |
Synonyms : | POLR2C; polymerase (RNA) II (DNA directed) polypeptide C, 33kDa; polymerase (RNA) II (DNA directed) polypeptide C (33kD); DNA-directed RNA polymerase II subunit RPB3; RNA polymerase II subunit 3; RPB3; RPB33; RNA polymerase II subunit B3; DNA-directed RNA polymerase II subunit C; DNA-directed RNA polymerase II 33 kDa polypeptide; RPB31; hRPB33; hsRPB3; |
Gene ID : | 5432 |
mRNA Refseq : | NM_032940 |
Protein Refseq : | NP_116558 |
MIM : | 180663 |
UniProt ID : | P19387 |
Chromosome Location : | 16q13-q21 |
Pathway : | Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem; DNA Repair, organism-specific biosystem; Disease, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystem; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat, organism-specific biosystem; |
Function : | DNA binding; DNA-directed RNA polymerase activity; protein dimerization activity; contributes_to protein kinase activity; |
Products Types
◆ Recombinant Protein | ||
POLR2C-3332R | Recombinant Rhesus Macaque POLR2C Protein, His (Fc)-Avi-tagged | +Inquiry |
POLR2C-3055H | Recombinant Human POLR2C, T7-tagged | +Inquiry |
POLR2C-5579C | Recombinant Chicken POLR2C | +Inquiry |
POLR2C-1841H | Recombinant Human POLR2C, His-tagged | +Inquiry |
POLR2C-231H | Recombinant Human POLR2C, His-tagged | +Inquiry |
◆ Lysates | ||
POLR2C-3036HCL | Recombinant Human POLR2C 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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