"FGF7" Related Products

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Recombinant Human FGF7, His-tagged

Cat.No.: FGF7-8867H
Product Overview: Recombinant Human FGF7 was produced in the endosperm tissue of barley grain (Hordeum vulgare).
Description: Keratinocyte Growth Factor (KGF, FGF-7, HBGF-7) is a member of the FGF family of 23 related mitogenic proteins. These proteins play a central role during embryonic development and postnatal growth and tissue repair, by promoting cellular proliferation and differentiation. KGF specifically stimulates epithelial cells and keratinocytes, it is the most potent growth factor identified thus far for skin keratinocytes. KGF takes part in the development of kidney and lung, angiogenesis and has a key role in wound healing following skin injuries. It shows considerable species cross-reactivity (mouse, monkey, porcine cells) as the other members of the FGF family.
Source: Hordeum vulgare
Species: Human
Predicted N Terminal: His
Form: Sterile filtered through a 0.2 μm filter. Lyophilized from PBS, pH 7.2
Bio-activity: The bioactivity of recombinant human KGF was determined by its dose dependent effect on proliferation of 4MBr5 rhesus monkey epithelial cells. The ED50 for this effect is typically below 4 ng/ml corresponding to specific activity of >2.5 x 10e5 U/mg.
Molecular Mass: Recombinant human KGF contains 164 amino acids and a 16 a.a. histidine-based tag for a total length of 180 a.a. and has a predicted molecular mass of 21.2 kDa including his-tag. As a result of glycosylation, the recombinant protein migrates as two bands with an apparent molecular mass of 30 and 38 kDa in SDS-PAGE.
Endotoxin: Endotoxin level is less than 0.05EU/μg as measured by turbidimetric kinetic assay.
Purity: >95% by SDS-PAGE gel analysis.
Storage: The lyophilized protein is stable at room temperature for few weeks. Reconstituted protein should be used immediately or stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile water to a concentration of no less than 100 μg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Gene Name: FGF7 fibroblast growth factor 7 [ Homo sapiens ]
Official Symbol: FGF7
Synonyms: FGF7; fibroblast growth factor 7; fibroblast growth factor 7 (keratinocyte growth factor); keratinocyte growth factor; KGF; FGF-7; heparin-binding growth factor 7; HBGF-7;
Gene ID: 2252
mRNA Refseq: NM_002009
Protein Refseq: NP_002000
MIM: 148180
UniProt ID: P21781
Chromosome Location: 15q21.2
Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR2 ligand binding and activation, organism-specific biosystem; FGFR2b ligand binding and activation, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; Glypican 3 network, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem;
Function: chemoattractant activity; growth factor activity; heparin binding; type 2 fibroblast growth factor receptor binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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