"IL15" Related Products

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Recombinant Human IL15 protein, His-tagged

Cat.No. : IL15-45H
Product Overview : Recombinant Human IL15(49-162) fused with His tag at C-terminal was expressed in E. coli.
Description : The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
Source : E. coli
Species : Human
Tag : His
Form : IL-15 His is supplied in 20mM Tris-HCl buffer (pH 8.0) 0.2mM PMSF and 10% glycerol.
Bio-activity : Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is < 2.5ng/ml, corresponding to a Specific Activity of 400,000units/mg.
Molecular Mass : 13.9 kDa
AA Sequence : MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTSLEHHH HHH.
Purity : Greater than 95.0% as determined by SDS-PAGE.
Stability : Store at 4 centigrade if entire vial will be used within 2-4 weeks.Store, frozen at -20 centigrade for longer periods of time.Please avoid freeze thaw cycles.
Gene Name : IL15 interleukin 15 [ Homo sapiens ]
Official Symbol : IL15
Synonyms : IL15; interleukin 15; interleukin-15; IL 15; MGC9721; IL-15;
Gene ID : 3600
mRNA Refseq : NM_000585
Protein Refseq : NP_000576
MIM : 600554
UniProt ID : P40933
Chromosome Location : 4q31
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem;
Function : cytokine activity; cytokine receptor binding; protein binding;

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