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Recombinant Human Prominin 1, GST-tagged

Cat.No. : PROM1-73H
Product Overview : Recombinant Human PROM1 (693 a.a. - 790 a.a.) fused with GST-tag at N-terminal, was expressed in wheat germ.
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  • Gene Information
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Cat. No. : PROM1-73H
Description : This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : wheat germ
Molecular Mass : 36.52 kDa
Sequence : STLYQSVKILQRTGNGLLERVTRIL ASLDFAQNFITNNTSSVIIEETKKY GRTIIGYFEHYLQWIEFSISEKVAS CKPVATALDTAVDVFLCSYIIDP
Storagebuffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
Applications : ELISA; WB
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
OfficialSymbol : PROM1
Gene Name : PROM1 prominin 1 [Homo sapiens]
Synonyms : prominin 1; prominin (mouse)-like 1; AC133; Stargardt disease 4 (autosomal dominant); CD133; OTTHUMP00000217744; RP41; OTTHUMP00000217745; PROML1; OTTHUMP00000217746; Antigen AC133; hProminin; Prominin-like protein 1; hematopoietic stem cell antigen; CORD12; prominin-1; MCDR2; prominin-like 1; STGD4; CD133 antigen; macular dystrophy, retinal 2; MSTP061
Gene ID : 8842
mRNA Refseq : NM_006017
Protein Refseq : NP_006008
MIM : 604365
UniProt ID : O43490
Chromosome Location : 4p15.32
Function : actinin binding; cadherin binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there specific diseases where PROM1 protein is extensively studied? 01/25/2022

Yes, PROM1's role is widely studied in various cancers, including brain, breast, colon, and pancreatic cancers.

What methods are used to study PROM1 protein in clinical settings? 10/24/2021

Various laboratory techniques, such as flow cytometry, immunohistochemistry, and molecular biology assays, are employed to study PROM1 expression and function.

Is PROM1 exclusively related to cancer and regenerative medicine? 01/05/2019

No, PROM1 is also associated with certain eye disorders and is being researched for potential applications in retinal diseases.

Can PROM1 be a potential target for therapeutic interventions? 08/10/2016

Research suggests that it could be a target for treatments aimed at eliminating cancer stem cells and potentially preventing cancer relapse.

Are there any side effects associated with targeting PROM1 in therapies? 03/06/2016

The potential impact on normal stem cells and unintended consequences on healthy tissues are areas of concern when targeting PROM1 for therapies.

Customer Reviews (3)

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Reviews
05/01/2021

    They can offer detailed characterization data, including purity, stability, and functional assessments, to support researchers' confidence in using the protein in their trials.

    10/01/2017

      Manufacturers can support researchers in developing assays to measure PROM1 protein levels or activity specific to their clinical trial settings.

      12/14/2016

        This may involve guidance in selecting appropriate detection methods, providing assay components, or optimizing protocols for optimal performance and sensitivity.

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