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Recombinant Rat Nr1h4, His-tagged

Cat.No. : Nr1h4-07R
Product Overview : The Recombinant Rat Nr1h4, His-tagged protein was expressed in E. coli and purified by affinity chromatography in combination with FPLC columns.
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Description : Farnesoid-X-receptor (FXR) was originally identified and cloned in rat as an orphan nuclear hormone receptor based on hybridization with a degenerate oligonucleotide designed from the highly conserved nuclear hormone receptor DNA binding domain. FXR functions as a heterodimer with RXR and binds to sequence elements in the promoters of target genes. The FXR/RXR heterodimer binds with highest affinity to inverted repeats separated by 1 bp (IR-1) and with low affinity to direct repeats separated by 4 and 5 bp (DR-4 and DR-5). As is the case for other nuclear hormone receptors, FXR regulates target gene activity in response to ligand. While initial studies suggested that farnesol and retinoid metabolites were likely ligands for FXR, current data support the notion that FXR is a bile acid sensor that plays an integral role in bile acid synthesis and transport.
Source : E. coli
Species : Rat
Tag : His
Form : The protein is in 20mM Tris-HCl pH7.9,100mM NaCl, 0.2mM EDTA, 1mM DTT and 20% glycerol.
Molecular Mass : 56.6 kDa.
AA Sequence : MVMQFQGLEN PIQISLQHSH RLSGFASDRM SSKPAKGVLT EHAAGPLGQN LDLESYSPYN NVQFPQVQPQ ISSSSYYSNL GFYPQQPEDW YSPGLYELRR MPTESVYQGE TEVSEMPVTK KPRMAASSAG RIKGDELCVV CGDRASGYHY NALTCEGCKG FFRRSITKNA VYKCKNGGNC VMDMYMRRKC QDCRLRKCRE MGMLAECLLT EIQCKSKRLR KNVKQHADQT VNEDSEGRDL RQVTSTTKLC REKTELTVDQ QTLLDYIMDS YSKQRMPQEI TNKILKEEFS AEENFLILTE MATSHVQILV EFTKRLPGFQ TLDHEDQIAL LKGSAVEAMF LRSAEIFNKK LPAGHADLLE ERIRKSGISD EYITPMFSFY KSVGELKMTQ EEYALLTAIV ILSPDRQYIK DREAVEKLQE PLLDVLQKLC KIYQPENPQH FACLLGRLTE LRTFNHHHAE MLMSWRVNDH KFTPLLCEIW DVQ
Purity : Greater than 90% as determined by SDS-PAGE.
Storage : Stored at -70°C before use. Avoid repeated freeze thaw cycles.
Gene Name : Nr1h4 nuclear receptor subfamily 1, group H, member 4 [ Rattus norvegicus ]
Official Symbol : Nr1h4
Synonyms : NR1H4; nuclear receptor subfamily 1, group H, member 4; bile acid receptor; farnesol receptor HRR-1; RXR-interacting protein 14; farnesoid X activated receptor; farnesoid X-activated receptor; retinoid X receptor-interacting protein 14; Fxr; MGC94878;
Gene ID : 60351
mRNA Refseq : NM_021745
Protein Refseq : NP_068513
UniProt ID : Q62735
Chromosome Location : 7q13
Pathway : Bile secretion, organism-specific biosystem;Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem
Function : DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding; bile acid binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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