Active Recombinant Human PDGFA
Cat.No. : | PDGFA-101H |
Product Overview : | Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids). Manufactured using all non-animal reagents. |
- Specification
- Gene Information
- Related Products
Description : | PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. |
Source : | E. coli |
Species : | Human |
Bio-activity : | The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. |
AA Sequence : | SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT |
Purity : | Greater than 98% by SDS-PAGE gel and HPLC analyses. |
Storage : | Store at -20°C. Avoid repeated freeze-thaw cycles. |
Gene Name : | PDGFA platelet-derived growth factor alpha polypeptide [ Homo sapiens ] |
Official Symbol : | PDGFA |
Synonyms : | PDGFA; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A; PDGF A chain; PDGF A; PDGF1; platelet derived growth factor alpha chain; PDGF-1; PDGF A-chain; PDGF subunit A; platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; PDGF-A; |
Gene ID : | 5154 |
mRNA Refseq : | NM_002607 |
Protein Refseq : | NP_002598 |
MIM : | 173430 |
UniProt ID : | P04085 |
Chromosome Location : | 7p22 |
Pathway : | Ceramide signaling pathway, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; Downstream signal transduction, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; |
Function : | cell surface binding; collagen binding; eukaryotic cell surface binding; growth factor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; contributes_to platelet-derived growth factor receptor binding; platelet-derived growth factor receptor binding; protein heterodimerization activity; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
PDGFA-32H | Recombinant Human PDGFA Protein | +Inquiry |
PDGFA-923C | Recombinant Canine PDGFA Protein (Ser87-Arg196), His-tagged | +Inquiry |
PDGFA-2569H | Recombinant Human PDGFA Protein, His-tagged | +Inquiry |
PDGFA-222H | Active Recombinant Human PDGF-AB Protein | +Inquiry |
PDGFA-1608H | Recombinant Human PDGFA protein, GST-tagged | +Inquiry |
◆ Lysates | ||
PDGFA-3337HCL | Recombinant Human PDGFA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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