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Recombinant Human ACACA, His-tagged

Cat.No.: ACACA-9262H
Product Overview: Recombinant Human ACACA protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5 sequence and encoding distinct isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: His
Protein length: C-term-124a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: ACACA acetyl-CoA carboxylase alpha [ Homo sapiens ]
Official Symbol: ACACA
Synonyms: ACACA; acetyl-CoA carboxylase alpha; ACAC, ACC, acetyl Coenzyme A carboxylase alpha; acetyl-CoA carboxylase 1; ACC1; acetyl CoA carboxylase 1; ACC-alpha; acetyl-Coenzyme A carboxylase alpha; ACC; ACAC; ACCA; ACACAD;
Gene ID: 31
mRNA Refseq: NM_198834
Protein Refseq: NP_942131
MIM: 200350
UniProt ID: Q13085
Chromosome Location: 17q21
Pathway: AMPK signaling, organism-specific biosystem; ChREBP activates metabolic gene expression, organism-specific biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty Acyl-CoA Biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem;
Function: ATP binding; acetyl-CoA carboxylase activity; biotin binding; biotin carboxylase activity; ligase activity; metal ion binding; nucleotide binding; protein binding;

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