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Recombinant Human AGER, GST-tagged

Cat.No.: AGER-9468H
Product Overview: Recombinant Human AGER protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimers disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
Source: E.coli
Species: Human
Tag: GST
Protein length: 26-340a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: AGER advanced glycosylation end product-specific receptor [ Homo sapiens ]
Official Symbol: AGER
Synonyms: AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta;
Gene ID: 177
mRNA Refseq: NM_001136
Protein Refseq: NP_001127
MIM: 600214
UniProt ID: Q15109
Chromosome Location: 6p21.3
Pathway: Activated TLR4 signalling, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem; DAI mediated induction of type I IFNs, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem;
Function: S100 alpha binding; advanced glycation end-product receptor activity; protein binding; receptor activity; receptor activity; transmembrane signaling receptor activity;

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