Recombinant Human APPL1, GST-tagged

• Cat.No.: APPL1-9774H
• Product Overview: Recombinant Human APPL1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-323a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 [ Homo sapiens ]
• Official Symbol: APPL1
• Synonyms: APPL1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; DCC-interacting protein 13-alpha; APPL; dip13-alpha; AKT2 interactor; signaling adaptor protein DIP13alpha; adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein containing pH domain, PTB domain and leucine zipper motif 1; DIP13alpha
• Gene ID: 26060
• mRNA Refseq: NM_012096
• Protein Refseq: NP_036228
• MIM: 604299
• UniProt ID: Q9UKG1
• Chromosome Location: 3p21.1-p14.3
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Pathways in cancer, organism-specific biosystem
• Function: protein binding; protein kinase B binding