Recombinant Human ATP1B2, His-tagged

• Cat.No.: ATP1B2-10008H
• Product Overview: Recombinant Human ATP1B2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 64-171a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide [ Homo sapiens ]
• Official Symbol: ATP1B2
• Synonyms: ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide; sodium/potassium-transporting ATPase subunit beta-2; AMOG; adhesion molecule on glia; Na, K-ATPase beta-2 polypeptide; sodium/potassium-dependent ATPase beta-2 subunit; sodium/potassium-dependent ATPase subunit beta-2; sodium/potassium-transporting ATPase beta-2 chain
• Gene ID: 482
• mRNA Refseq: NM_001678
• Protein Refseq: NP_001669
• MIM: 182331
• UniProt ID: P14415
• Chromosome Location: 17p13.1
• Pathway: Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Basigin interactions, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Carbohydrate digestion and absorption, organism-specific biosystem
• Function: protein binding; sodium:potassium-exchanging ATPase activity