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Recombinant Human BACE2, GST-tagged

Cat.No. : BACE2-10121H
Product Overview : Recombinant Human BACE2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the Down critical region of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
Source : E.coli
Species : Human
Tag : GST
Protein length : 39-398a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : BACE2 beta-site APP-cleaving enzyme 2 [ Homo sapiens ]
Official Symbol : BACE2
Synonyms : BACE2; beta-site APP-cleaving enzyme 2; AEPLC; beta-secretase 2; ALP56; CEAP1; DRAP; asp 1; memapsin-1; theta-secretase; beta secretase 2; aspartyl protease 1; 56 kDa aspartic-like protease; aspartic-like protease 56 kDa; down region aspartic protease; beta-site APP cleaving enzyme 2; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid precursor protein cleaving enzyme 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; ASP1; BAE2; ASP21; CDA13;
Gene ID : 25825
mRNA Refseq : NM_012105
Protein Refseq : NP_036237
MIM : 605668
UniProt ID : Q9Y5Z0
Chromosome Location : 21q22.3
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem;
Function : aspartic-type endopeptidase activity; peptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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