Recombinant Human CENPJ, GST-tagged

• Cat.No.: CENPJ-11097H
• Product Overview: Recombinant Human CENPJ protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-term-306a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CENPJ centromere protein J [ Homo sapiens ]
• Official Symbol: CENPJ
• Synonyms: CENPJ; centromere protein J; MCPH6, microcephaly, primary autosomal recessive 6; BM032; CPAP; LAP; LIP1; Sas 4; SASS4; SCKL4; LAG-3-associated protein; LYST-interacting protein 1; LYST-interacting protein LIP1; LYST-interacting protein LIP7; centrosomal P4.1-associated protein; MCPH6; Sas-4; CENP-J; MGC131581; MGC131582; MGC142222; MGC142224
• Gene ID: 55835
• mRNA Refseq: NM_018451
• Protein Refseq: NP_060921
• MIM: 609279
• UniProt ID: Q9HC77
• Chromosome Location: 13q12.12
• Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem; Mitotic G2-G2/M phases, organism-specific biosystem
• Function: protein binding; protein domain specific binding; protein kinase binding; tubulin binding