"E2F4" Related Products

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Recombinant Human E2F4, GST-tagged

Cat.No.: E2F4-12248H
Product Overview: Recombinant Human E2F4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-413a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: E2F4 E2F transcription factor 4, p107/p130-binding [ Homo sapiens ]
Official Symbol: E2F4
Synonyms: E2F4; E2F transcription factor 4, p107/p130-binding; transcription factor E2F4; E2F 4; p107/p130-binding protein; E2F-4;
Gene ID: 1874
mRNA Refseq: NM_001950
Protein Refseq: NP_001941
MIM: 600659
UniProt ID: Q16254
Chromosome Location: 16q21-q22
Pathway: Adipogenesis, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Cyclin D associated events in G1, organism-specific biosystem;
Function: DNA binding; protein binding; protein domain specific binding; sequence-specific DNA binding transcription factor activity; transcription factor binding;

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