Recombinant Human FBXL14, His-tagged

• Cat.No.: FBXL14-12772H
• Product Overview: Recombinant Human FBXL14 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-418a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: FBXL14 F-box and leucine-rich repeat protein 14 [ Homo sapiens ]
• Official Symbol: FBXL14
• Synonyms: FBXL14; F-box and leucine-rich repeat protein 14; F-box/LRR-repeat protein 14; Fbl14; MGC40195
• Gene ID: 144699
• mRNA Refseq: NM_152441
• Protein Refseq: NP_689654
• MIM: 609081
• UniProt ID: Q8N1E6
• Chromosome Location: 12p13.33
• Function: protein binding; ubiquitin-protein ligase activity