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Recombinant Human FGG, His-tagged

Cat.No. : FGG-12884H
Product Overview : Recombinant Human FGG protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
Source : E.coli
Species : Human
Tag : His
Protein length : C-term-348a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : FGG fibrinogen gamma chain [ Homo sapiens ]
Official Symbol : FGG
Synonyms : FGG; fibrinogen gamma chain; fibrinogen, gamma polypeptide;
Gene ID : 2266
mRNA Refseq : NM_000509
Protein Refseq : NP_000500
MIM : 134850
UniProt ID : P02679
Chromosome Location : 4q28
Pathway : Blood Clotting Cascade, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem;
Function : eukaryotic cell surface binding; protein binding, bridging; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does the FGG gene expression respond to inflammatory stimuli and cytokines? 03/12/2021

Inflammatory stimuli and cytokines can modulate FGG gene expression, influencing the synthesis of fibrinogen gamma chain during inflammatory responses.

How does FGG gamma chain participate in the polymerization of fibrin during clot formation? 05/19/2020

The FGG gamma chain, along with alpha and beta chains, contributes to the polymerization of fibrin by forming intermolecular bonds between fibrin molecules.

What is the role of FGG in the blood coagulation cascade? 10/05/2019

Fibrinogen is a crucial factor in blood coagulation, as it is converted to fibrin during the final stages of the coagulation cascade, forming a stable blood clot.

What is the significance of FGG in wound healing and tissue repair processes? 12/31/2018

Fibrinogen (FGG), converted to fibrin, forms the matrix for blood clotting at wound sites, facilitating tissue repair and providing a scaffold for cell migration.

How does the FGG gene contribute to the synthesis of fibrinogen in hepatocytes? 02/14/2018

The FGG gene is transcribed in hepatocytes, and the resulting mRNA is translated into the fibrinogen gamma chain during the synthesis of fibrinogen.

Customer Reviews (3)

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07/28/2021

    This product consistently delivers accurate results in our experiments.

    11/11/2020

      Ordered, and this product was in our hands sooner than expected, facilitating our research timeline.

      02/12/2018

        Quick service! The team provided efficient assistance in choosing the right protein for us.

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