Recombinant Human FGG, His-tagged
Cat.No. : | FGG-12884H |
Product Overview : | Recombinant Human FGG protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | C-term-348a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | FGG fibrinogen gamma chain [ Homo sapiens ] |
Official Symbol : | FGG |
Synonyms : | FGG; fibrinogen gamma chain; fibrinogen, gamma polypeptide; |
Gene ID : | 2266 |
mRNA Refseq : | NM_000509 |
Protein Refseq : | NP_000500 |
MIM : | 134850 |
UniProt ID : | P02679 |
Chromosome Location : | 4q28 |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; |
Function : | eukaryotic cell surface binding; protein binding, bridging; receptor binding; |
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◆ Native Protein | ||
FGG -44D | Native Canine Fibrinogen, FITC Labeled | +Inquiry |
Fgg -65R | Native Rat Fibrinogen, FITC Labeled | +Inquiry |
FGG-53S | Native Sheep Fibrinogen | +Inquiry |
◆ Lysates | ||
FGG-6231HCL | Recombinant Human FGG 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionInflammatory stimuli and cytokines can modulate FGG gene expression, influencing the synthesis of fibrinogen gamma chain during inflammatory responses.
The FGG gamma chain, along with alpha and beta chains, contributes to the polymerization of fibrin by forming intermolecular bonds between fibrin molecules.
Fibrinogen is a crucial factor in blood coagulation, as it is converted to fibrin during the final stages of the coagulation cascade, forming a stable blood clot.
Fibrinogen (FGG), converted to fibrin, forms the matrix for blood clotting at wound sites, facilitating tissue repair and providing a scaffold for cell migration.
The FGG gene is transcribed in hepatocytes, and the resulting mRNA is translated into the fibrinogen gamma chain during the synthesis of fibrinogen.
Customer Reviews (3)
Write a reviewThis product consistently delivers accurate results in our experiments.
Ordered, and this product was in our hands sooner than expected, facilitating our research timeline.
Quick service! The team provided efficient assistance in choosing the right protein for us.
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