Recombinant Human GAD2, GST-tagged
Cat.No. : | GAD2-13107H |
Product Overview : | Recombinant Human GAD2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-180a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) [ Homo sapiens ] |
Official Symbol : | GAD2 |
Synonyms : | GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 2 (pancreatic islets and brain, 65kD); glutamate decarboxylase 2; GAD65; GAD-65; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 65 kDa isoform; MGC161605; MGC161607; |
Gene ID : | 2572 |
mRNA Refseq : | NM_000818 |
Protein Refseq : | NP_000809 |
MIM : | 138275 |
UniProt ID : | Q05329 |
Chromosome Location : | 10p13-p11.2 |
Pathway : | Alanine and aspartate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Butanoate metabolism, organism-specific biosystem; Butanoate metabolism, conserved biosystem; GABA (gamma-Aminobutyrate) shunt, organism-specific biosystem; |
Function : | carboxy-lyase activity; glutamate decarboxylase activity; lyase activity; protein binding; pyridoxal phosphate binding; |
Products Types
◆ Recombinant Protein | ||
GAD2-9170H | Recombinant Human GAD2 Protein, N-His tagged | +Inquiry |
GAD2-1557H | Recombinant Human GAD2 Protein, His-tagged | +Inquiry |
GAD2-1303M | Recombinant Mouse GAD2 protein(Met1-Leu585) | +Inquiry |
Gad2-3129M | Recombinant Mouse Gad2 Protein, Myc/DDK-tagged | +Inquiry |
GAD2-512M | Recombinant Mouse GAD2 Protein (1-585 aa), His-tagged | +Inquiry |
◆ Lysates | ||
GAD2-001MCL | Recombinant Mouse GAD2 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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