"HLA-DPA1" Related Products

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Recombinant Human HLA-DPA1, GST-tagged

Cat.No.: HLA-DPA1-13816H
Product Overview: Recombinant Human HLA-DPA1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Source: E.coli
Species: Human
Tag: GST
Protein length: 32-224a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 [ Homo sapiens ]
Official Symbol: HLA-DPA1
Synonyms: HLA-DPA1; major histocompatibility complex, class II, DP alpha 1; HLA DP1A; HLA class II histocompatibility antigen, DP alpha 1 chain; MHC class II DPA1; HLA-SB alpha chain; MHC class II antigen; MHC class II DP3-alpha; Primed lymphocyte test-1; MHC class II HLA-DPA1 antigen; HLA class II histocompatibility antigen, DP alpha chain; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A;
Gene ID: 3113
mRNA Refseq: NM_001242524
Protein Refseq: NP_001229453
MIM: 142880
UniProt ID: P20036
Chromosome Location: 6p21.3
Pathway: Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem;
Function: MHC class II receptor activity;

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