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Recombinant Human NRG1, Fc tagged

Cat.No. : NRG1-10H
Product Overview : Recombinant Human NRG1 (Q02297-1) isoform alpha extracellular domain (Ser 20-Lys 241), fused with the Fc region of human IgG1 at the C-terminus, was produced in Human Cell.
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  • Gene Information
  • Related Products
Source : Human Cells
Species : Human
Tag : Fc
Form : Lyophilized from 0.2μm filtered solution of PBS, pH 7.4
Molecular Mass : The recombinant human NRG1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 463 amino acids and has a calculated molecular mass of 51 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NRG1/Fc monomer is approximately 60 kDa.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : NRG1 neuregulin 1 [ Homo sapiens ]
Official Symbol : NRG1
Gene ID : 3084
mRNA Refseq : NM_001159995
Protein Refseq : NP_001153467
MIM : 142445
UniProt ID : Q02297

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is NRG1 implicated in neural development and synaptic plasticity? 06/09/2022

NRG1 is essential for neural development, influencing neuronal migration, myelination, and synapse formation. It also plays a role in synaptic plasticity, modulating neurotransmission and synaptic strength.

What role does NRG1 play in cardiac development and function? 12/01/2019

In the heart, NRG1 is involved in the regulation of cardiac development, including trabeculation. It also has protective effects on cardiac muscle cells and can influence heart repair mechanisms.

Are there any associations between NRG1 mutations or dysregulation and diseases? 01/15/2019

Dysregulation of NRG1 signaling has been implicated in several diseases, including schizophrenia, multiple sclerosis, and certain types of cancers. Genetic variations in the NRG1 gene have been associated with increased risk for some of these conditions.

What are the therapeutic implications of targeting NRG1 in various diseases? 09/18/2018

Given the diverse roles of NRG1 in various physiological processes, it presents as a potential therapeutic target. For instance, recombinant NRG1 has been explored for heart failure treatment, and its modulation is being studied in the context of neural disorders and cancers.

Are there different isoforms of NRG1, and how do they differ in function? 05/29/2018

Yes, there are multiple isoforms of NRG1, generated through alternative splicing. These isoforms can differ in their tissue distribution, receptor binding, and functional roles.

How does NRG1 interact with its receptor, and what are the downstream signaling pathways activated? 03/17/2018

NRG1 primarily interacts with the ErbB family of tyrosine kinase receptors, especially ErbB3 and ErbB4. Upon binding, it activates downstream pathways such as the PI3K/Akt and MAPK pathways.

What is the primary biological function of the NRG1 protein? 02/16/2018

NRG1 is a versatile signaling molecule that plays crucial roles in the development and function of multiple organ systems, including the nervous system, heart, and breast.

Customer Reviews (3)

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Reviews
08/12/2022

    Excellent results, very consistent.

    01/27/2021

      Worked great in assays.

      01/02/2019

        Great product, very reliable.

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