Active Recombinant Mouse Kitl
Cat.No. : | Kitl-208M |
Product Overview : | Recombinant mouse Stem Cell Factor (rmSCF) produced in P. pastoris is a single glycosylated polypeptide chain containing 165 amino acids. |
- Specification
- Gene Information
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Description : | Stem Cell Factor (SCF) is a hematopoietic growth factor that binds to the c-Kit receptor. SCF exerts its activity during the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. |
Source : | P. pastoris |
Species : | Mouse |
Form : | Lyophilized after extensive dialysis against 50mM Tris, pH8.0. |
Bio-activity : | ED50< 10.0 ng/ml, measured by a cell proliferation assay using human tf-1 cells, corresponding to a specific activity of>1.0× 105 units/mg. |
Molecular Mass : | 18.4kDa, observed by reducing SDS-PAGE. |
AA Sequence : | Lys26-Ala189, expressed with an N-terminal Met. |
Endotoxin : | < 0.2 eu/μg, determined by lal> |
Purity : | >95% by SDS-PAGE and HPLC analyses. |
Storage : | Lyophilized recombinant protein remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmSCF should be stable up to 2 weeks at 4°C or up to 3 months at -20°C. |
Reconstitution : | Reconstituted in ddH2O at 100 μg/ml. |
Gene Name : | Kitl kit ligand [ Mus musculus ] |
Official Symbol : | Kitl |
Synonyms : | KITL; kit ligand; cloud gray; C-kit ligand; Steel factor; grizzle-belly; stem cell factor; mast cell growth factor; hematopoietic growth factor KL; Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; Kitlg; contrasted; |
Gene ID : | 17311 |
mRNA Refseq : | NM_013598 |
Protein Refseq : | NP_038626 |
UniProt ID : | P20826 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Kit Receptor Signaling Pathway, organism-specific biosystem; Melanogenesis, organism-specific biosystem; Melanogenesis, conserved biosystem; |
Function : | cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding; |
Products Types
◆ Recombinant Protein | ||
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KITLG-217H | Active Recombinant Human KITLG Protein (Glu26-Ala189), C-His tagged, Animal-free, Carrier-free | +Inquiry |
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KITLG-4388C | Recombinant Canine KITLG Protein | +Inquiry |
◆ Lysates | ||
KITLG-583MCL | Recombinant Mouse KITLG cell lysate | +Inquiry |
KITLG-571HCL | Recombinant Human KITLG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionOverexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.
Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.
KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.
Customer Reviews (3)
Write a reviewReliable for immunoprecipitation assay.
No contamination, very clean.
Worked perfectly in Western.
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