Active Recombinant Human IL1B
Cat.No. : | IL1B-9908H |
Product Overview : | Recombinant Human IL1B was expressed in CHO Cells. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin 1 beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine. |
Source : | CHO Cells |
Species : | Human |
Form : | Lyophilized after extensive dialysis against PBS. |
Bio-activity : | ED50< 10 pg/ml, measured in a cell proliferation assay using d10s cells, corresponding to a specific activity of>1 x 108 units/mg. |
Molecular Mass : | 17kDa, observed by non-reducing SDS-PAGE. |
AA Sequence : | Ala117-Ser269. |
Endotoxin : | <0.2 eu/μg, determined by lal>0.2> |
Purity : | >95% as analyzed by SDS-PAGE and HPLC. |
Storage : | Lyophilized recombinant protein remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhIL-1β should be stable up to 1 week at 4°C or up to 2 months at -20°C. |
Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/ml. |
Gene Name : | IL1B interleukin 1, beta [ Homo sapiens ] |
Official Symbol : | IL1B |
Synonyms : | IL1B; interleukin 1, beta; interleukin-1 beta; IL 1B; IL1 BETA; IL1F2; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; IL-1; IL1-BETA; |
Gene ID : | 3553 |
mRNA Refseq : | NM_000576 |
Protein Refseq : | NP_000567 |
MIM : | 147720 |
UniProt ID : | P01584 |
Chromosome Location : | 2q14 |
Pathway : | African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Apoptosis, organism-specific biosystem; |
Function : | cytokine activity; cytokine activity; growth factor activity; interleukin-1 receptor binding; protein domain specific binding; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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