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Recombinant human ITGB1, His-tagged

Cat.No. : ITGB1-2484H
Product Overview : Recombinant human ITGB1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
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Description : Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Molecular Mass : 51.2kDa (462aa)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MQTDENRCLK ANAKSCGECI QAGPNCGWCT NSTFLQEGMP TSARCDDLEA LKKKGCPPDD IENPRGSKDI KKNKNVTNRS KGTAEKLKPE DITQIQPQQL VLRLRSGEPQ TFTLKFKRAE DYPIDLYYLM DLSYSMKDDL ENVKSLGTDL MNEMRRITSD FRIGFGSFVE KTVMPYISTT PAKLRNPCTS EQNCTSPFSY KNVLSLTNKG EVFNELVGKQ RISGNLDSPE GGFDAIMQVA VCGSLIGWRN VTRLLVFSTD AGFHFAGDGK LGGIVLPNDG QCHLENNMYT MSHYYDYPSI AHLVQKLSEN NIQTIFAVTE EFQPVYKELK NLIPKSAVGT LSANSSNVIQ LIIDAYNSLS SEVILENGKL SEGVTISYKS YCKNGVNGTG ENGRKCSNIS IGDEVQFEIS ITSNKCPKKD SDSFKIRPLG FTEEVEVILQ YI
Purity : >80 % by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [ Homo sapiens ]
Official Symbol : ITGB1
Synonyms : ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); FNRB, MDF2, MSK12; integrin beta-1; CD29; GPIIA; integrin VLA-4 beta subunit; very late activation protein, beta polypeptide; FNRB; MDF2; VLAB; MSK12; VLA-BETA;
Gene ID : 3688
mRNA Refseq : NM_002211
Protein Refseq : NP_002202
MIM : 135630
UniProt ID : P05556
Chromosome Location : 10p11.2
Pathway : Adaptive Immune System, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem;
Function : actin binding; alpha-actinin binding; collagen binding; fibronectin binding; glycoprotein binding; integrin binding; laminin binding; peptide binding; protease binding; protein binding; protein domain specific binding; protein heterodimerization activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there have therapeutic strategies for ITGB1 protein? 08/20/2023

Therapeutic strategies for ITGB1 protein may include inhibiting its expression, blocking its binding to ligands, or regulating its associated signal transduction pathways. These methods may have potential applications in cancer treatment.

What are the interactions between ITGB1 protein and other proteins? 04/14/2023

The ITGB1 protein can interact with a variety of other proteins, including ligands, proteins in signal transduction pathways, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.

How about the specific role of ITGB1 protein in cancer? 04/18/2022

In cancer, ITGB1 protein may play a role by promoting processes such as the proliferation, migration and invasion of tumor cells, thus promoting the occurrence and development of tumors. It could be a potential target for cancer treatment.

Which is the main function of ITGB1 protein in cells? 03/31/2022

The main function of ITGB1 protein in cells is to act as a cell adhesion receptor, participate in the interaction between cells and extracellular matrix, and play an important role in cell migration and signal transduction.

What is the relationship between ITGB1 protein structure and function? 12/05/2020

The structure of the ITGB1 protein determines its ability and stability to bind to ligands. The study of its structure can help us understand its function and mechanism of action.

How about the association between ITGB1 protein expression level and disease? 02/23/2020

Recent literature has shown that the expression level of ITGB1 protein is related to the occurrence and development of a variety of diseases, including cancer, cardiovascular diseases, neurodegenerative diseases, etc.

Customer Reviews (3)

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Reviews
06/24/2023

    The range of applications for ITGB1 is impressive, and it can play an important role in any field.

    04/19/2023

      ITGB1 performed very well in Western blot, with clear bands and improved experimental accuracy.

      05/29/2021

        ITGB1 has a strong desensitization potential for specific allergens.

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