| Description : |
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins. |
| Source : |
Wheat germ |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
128.15 kDa |
| AA Sequence : |
MICQKFCVVLLHWEFIYVITAFNLS YPITPWRFKLSCMPPNSTYDYFLLP AGLSKNTSNSNGHYETAVEPKFNSS GTHFSNLSKTTFHCCFRSEQDRNCS LCADNIEGKTFVSTVNSLVFQQIDA NWNIQCWLKGDLKLFICYVESLFKN LFRNYNYKVHLLYVLPEVLEDSPLV PQKGSFQMVHCNCSVHECCECLVPV PTAKLNDTLLMCLKITSGGVIFQSP LMSVQPINMVKPDPPLGLHMEITDD GNLKISWSSPPLVPFPLQYQVKYSE NSTTVIREADKIVSATSLLVDSILP GSSYEVQVRGKRLDGPGIWSDWSTP RVFTTQDVIYFPPKILTSVGSNVSF HCIYKKENKIVPSKEIVWWMNLAEK IPQSQYDVVSDHVSKVTFFNLNETK PRGKFTYDAVYCCNEHECHHRYAEL YVIDVNINISCETDGYLTKMTCRWS TSTIQSLAESTLQLRYHRSSLYCSD IPSIHPISEPKDCYLQSDGFYECIF QPIFLLSGYTMWIRINHSLGSLDSP PTCVLPDSVVKPLPPSSVKAEITIN IGLLKISWEKPVFPENNLQFQIRYG LSGKEVQWKMYEVYDAKSKSVSLPV PDLCAVYAVQVRCKRLDGLGYWSNW SNPAYTVVMDIKVPMRGPEFWRIIN GDTMKKEKNVTLLWKPLMKNDSLCS VQRYVINHHTSCNGTWSEDVGNHTK FTFLWTEQAHTVTVLAINSIGASVA NFNLTFSWPMSKVNIVQSLSAYPLN SSCVIVSWILSPSDYKLMYFIIEWK NLNEDGEIKWLRISSSVKKYYIHDH FIPIEKYQFSLYPIFMEGVGKPKII NSFTQDDIEKHQSDAGLYVIVPVII SSSILLLGTLLISHQRMKKLFWEDV PNPKNCSWAQGLNFQKPETFEHLFI KHTASVTCGPLLLEPETISEDISVD TSWKNKDEMMPTTVVSLLSTTDLEK GSVCISDQFNSVNFSEAEGTEVTYE DESQRQPFVKYATLISNSKPSETGE EQGLINSSVTKCFSSKNSPLKDSFS NSSWEIEAQAFFILSDQHPNIISPH LTFSEGLDELLKLEGNFPEENNDKK SIYYLGVTSIKKRESGVLLTDKSRV SCPFPAPCLFTDIRVLQDSCSHFVE NNINLGTSSKKTFASYMPQFQTCST QTHKIMENKMCDLTV |
| Storage : |
Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
