"VEGFA" Related Products

Recombinant Mouse Vascular Endothelial Growth Factor 121

Cat. No.: VEGFA-47M
Product Overview: Recombinant Mouse Vascular Endothelial Growth Factor-121 produced inE.Coliis a homodimer, non-glycosylated, polypeptide chain containing 121 amino acids and having a molecular mass of 28.4 kDa. Recombinant Mouse VEGF-121 is a truncated version of Murine VEGF-165. The VEGF-121 is purified by proprietary chromatographic techniques.
Description: Vascular endothelial growth factor is an important signaling protein involved in both vasculogenesis and angiogenesis. As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells ). VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy.
Source: Escherichia Coli.
Amino Acid Sequence: MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKCDKRPRR.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: The protein was lyophilized from a concentrated (1mg/ml) solution with no additives.
Solubility: It is recommended to reconstitute the lyophilized VEGF-121 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage: Lyophilized VEGF-121 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution VEGF-121 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Synonyms: Vascular endothelial growth factor A; Vascular permeability factor; VEGF; MGC70609; VEGF-A; VPF; Vascular permeability factor; vascular endothelial growth factor; vascular endothelial growth factor isoform VEGF165; MVCD1; VEGFA.
Gene Name: Vegfa vascular endothelial growth factor A [ Mus musculus ]
Gene ID: 22339
mRNA Refseq: NM_001025250
Protein Refseq: NP_001020421
UniProt ID: Q00731
Chromosome Location: 17 C; 17 24.2 cM
Pathway: Bladder cancer; Focal adhesion; Cytokine-cytokine receptor interaction; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; VEGF signaling pathway; mTOR signaling pathway
Function: growth factor activity; heparin binding

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