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Recombinant Human GNE, His-tagged

Cat.No. : GNE-94H
Product Overview : Recombinant Human Bifunctional UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase/GNE is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Met1-Tyr722) of Human GNE fused with a 6His tag at the C-terminus.
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Description : Bifunctional UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase (GNE) contains two regions: UDP-N-acetylglucosamine 2-epimerase that belongs to the UDP-N-acetylglucosamine 2-epimerase family and N-acetylmannosamine kinase that belongs to the ROK (NagC/XylR) family. GNE localizes to the cytoplasm and exists as a homodimer and homohexamer. GNE is widely expressed, with the highest levels observed in the liver and placenta. GNE regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity, and metastatic behavior of malignant cells. In addition, GNE plays an essential role in early development.
Source : HEK293
Species : Human
Tag : His
AA Sequence : MEKNGNNRKLRVCVATCNRADYSKL APIMFGIKTEPEFFELDVVVLGSHL IDDYGNTYRMIEQDD FDINTRLHTIVRGEDEAAMVESVGL ALVKLPDVLNRLKPDIMIVHGDRFD ALALATSAALMNIRI LHIEGGEVSGTIDDSIRHAITKLAH YHVCCTRSAEQHLISMCEDHDRILL AGCPSYDKLLSAKNK DYMSIIRMWLGDDVKSKDYIVALQH PVTTDIKHSIKMFELTLDALISFNK RTLVLFPNIDAGSKE MVRVMRKKGIEHHPNFRAVKHVPFD QFIQLVAHAGCMIGNSSCGVREVGA FGTPVINLGTRQIGR ETGENVLHVRDADTQDKILQALHLQ FGKQYPCSKIYGDGNAVPRILKFLK SIDLQEPLQKKFCFP PVKENISQDIDHILETLSALAVDLG GTNLRVAIVSMKGEIVKKYTQFNPK TYEERINLILQMCVE AAAEAVKLNCRILGVGISTGGRVNP REGIVLHSTKLIQEWNSVDLRTPLS DTLHLPVWVDNDGNC AALAERKFGQGKGLENFVTLITGTG IGGGIIHQHELIHGSSFCAAELGHL VVSLDGPDCSCGSHG CIEAYASGMALQREAKKLHDEDLLL VEGMSVPKDEAVGALHLIQAAKLGN AKAQSILRTAGTALG LGVVNILHTMNPSLVILSGVLASHY IHIVKDVIRQQALSSVQDVDVVVSD LVDPALLGAASMVLD YTTRRIYVDHHHHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Gene Name : GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [ Homo sapiens ]
Official Symbol : GNE
Synonyms : GNE; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; IBM2, UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Uae1; N-acylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; NM; DMRV; IBM2; GLCNE;
Gene ID : 10020
mRNA Refseq : NM_001128227
Protein Refseq : NP_001121699
MIM : 603824
UniProt ID : Q9Y223
Chromosome Location : 9p13.1
Pathway : Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; CMP-N-acetylneuraminate biosynthesis I (eukaryotes), organism-specific biosystem; Metabolic pathways, organism-specific biosystem;
Function : ATP binding; N-acylmannosamine kinase activity; UDP-N-acetylglucosamine 2-epimerase activity; isomerase activity; kinase activity; nucleotide binding; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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