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Recombinant human IL1A

Cat.No.: IL1A-501H
Product Overview: Recombinant human IL1a (rhIL1a) Ser113-Ala271 (Accession# NP_000566) was produced in human HEK293 cells.
Description: Interleukin-1 alpha (IL1a) is also known as IL-1A, IL1, IL1-ALPHA,IL1F1,and is a cytokine of the interleukin-1 family. IL1a possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. IL-1α is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum.The constitutive production of large amounts of IL-1α precursor by healthy epidermal keratinocytes interfere with the important role of IL-1α in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1α possesses biological effect on cells in the picomolar to femtomolar range. In vivo, Shortly after an onset of an infection into organism, IL-1α activates a set of immune system response processes.
Source: HEK293
Species: Human
Form: Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder.Normally 5-8%. trehalose and mannitol are added as protectants before lyophilization.
Bio-activity: The bio-activity was determined by dose-dependent stimulation of the proliferation of mouse D10S cells. The ED50<1pg l, corresponding to a specific activity of>1X10^9 Unit/mg.
Molecular Mass: rhIL1a has a calculated MW of 18 kDa. DTT-reduced protein migrates as 22 kDa estimated polypeptide in SDS-PAGE.
Endotoxin: Less than 1.0 EU per 1 μg of the rhIL1a by the LAL method.
Purity: >97% as determined by SDS-PAGE. All lots are greater than 97% pure.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4 centigrade-8 centigrade); After reconstitution under sterile conditions for 1 month (4 centigrade-8 centigrade) or 3 months (-20 centigrade to -70 centigrade).
Gene Name: IL1A interleukin 1, alpha [ Homo sapiens ]
Official Symbol: IL1A
Synonyms: IL1A; interleukin 1, alpha; IL1; interleukin-1 alpha; hematopoietin 1; IL 1A; IL1 ALPHA; IL1F1; preinterleukin 1 alpha; pro interleukin 1 alpha; IL-1 alpha; hematopoietin-1; pro-interleukin-1-alpha; IL-1A; IL1-ALPHA;
Gene ID: 3552
mRNA Refseq: NM_000575
Protein Refseq: NP_000566
MIM: 147760
UniProt ID: P01583
Chromosome Location: 2q14
Pathway: Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem;
Function: copper ion binding; cytokine activity; interleukin-1 receptor binding; protein binding;

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