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Recombinant Human PDIA4, His-tagged

Cat.No. : PDIA4-125H
Product Overview : Recombinant Human Protein Disulfide-Isomerase A4/PDIA4 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Val21-Leu645) of Human PDIA4 fused with a polyhistidine tag at the C-terminus.
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Description : Protein Disulfide-Isomerase A4 (PDIA4) is an endoplasmic reticulum luminal protein that belongs to the protein disulfide isomerase family. Human PDIA4 is synthesized as a 625 amino acid precursor that contains a 20 amino acid signal sequence, and a 625 amino acid mature chain, including three thioredoxin domains. PDIA4 catalyzes the rearrangement of -S-S- bonds in proteins and is thought to be a deoxycytidine kinase. In addition, PDIA4 serves as a proteases protein disulfide isomerase, phospholipase or an arrangement of these.
Source : HEK293
Species : Human
Tag : His
AA Sequence : VAGAEGPDEDSSNRENAIEDEEEEE EEDDDEEEDDLEVKEENGVLVLNDA NFDNFVADKDTVLLE FYAPWCGHCKQFAPEYEKIANILKD KDPPIPVAKIDATSASVLASRFDVS GYPTIKILKKGQAVD YEGSRTQEEIVAKVREVSQPDWTPP PEVTLVLTKENFDEVVNDADIILVE FYAPWCGHCKKLAPE YEKAAKELSKRSPPIPLAKVDATAE TDLAKRFDVSGYPTLKIFRKGRPYD YNGPREK
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Gene Name : PDIA4 protein disulfide isomerase family A, member 4 [ Homo sapiens(human) ]
Official Symbol : PDIA4
Synonyms : PDIA4; ERP70; ERP72; ERp-72; protein disulfide isomerase family A, member 4; protein disulfide-isomerase A4; ER protein 70; ER protein 72; protein disulfide isomerase-associated 4; endoplasmic reticulum resident protein 70; endoplasmic reticulum resident protein 72; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); EC 5.3.4.1
Gene ID : 9601
mRNA Refseq : NM_004911
Protein Refseq : NP_004902
UniProt ID : P13667
Chromosome Location : 7q35
Pathway : Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Vibrio cholerae infection
Function : electron carrier activity; protein binding; protein disulfide isomerase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any diagnostic tests available to measure PDIA4 protein levels? 12/02/2021

Yes, there are immunoassays and other diagnostic tests available to measure PDIA4 protein levels in clinical samples.

How is PDIA4 protein involved in cardiovascular diseases? 12/13/2020

PDIA4 has been shown to play a role in the regulation of vascular function and endothelial cell survival, making it relevant to the pathophysiology of cardiovascular diseases.

Can PDIA4 protein be a potential target for therapeutic intervention in diabetes? 04/27/2019

Yes, research suggests that PDIA4 may play a role in insulin resistance and pancreatic beta-cell function, making it a potential target for therapeutic intervention in diabetes.

How does PDIA4 protein contribute to the pathogenesis of Alzheimer's disease? 07/04/2018

PDIA4 has been shown to be involved in the misfolding and aggregation of proteins associated with Alzheimer's disease, suggesting a potential role in disease progression.

Can PDIA4 protein be used as a therapeutic target for autoimmune diseases? 02/24/2016

Research has indicated that PDIA4 may be involved in the pathogenesis of autoimmune diseases, making it a potential therapeutic target for these conditions.

Customer Reviews (3)

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Reviews
05/20/2019

    Great performance in ELISA.

    08/08/2017

      The PDIA4 protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

      05/20/2017

        Its purity and functionality ensure precise and reproducible results, enabling me to achieve my research objectives with confidence.

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