"HPSE" Related Products

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Recombinant Human HPSE, His-tagged

Cat.No.: HPSE-5068H
Product Overview: Recombinant human HPSE protein, fused to His-tag at N-terminus, was expressed in E.coli.
Description: Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. HPSE is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
Molecular Mass: 60.0 kDa (531aa)
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSQDVVDLD FFTQEPLHLV SPSFLSVTID ANLATDPRFL ILLGSPKLRT LARGLSPAYL RFGGTKTDFL IFDPKKESTF EERSYWQSQV NQDICKYGSI PPDVEEKLRL EWPYQEQLLL REHYQKKFKN STYSRSSVDV LYTFANCSGL DLIFGLNALL RTADLQWNSS NAQLLLDYCS SKGYNISWEL GNEPNSFLKK ADIFINGSQL GEDFIQLHKL LRKSTFKNAK LYGPDVGQPR RKTAKMLKSF LKAGGEVIDS VTWHHYYLNG RTATKEDFLN PDVLDIFISS VQKVFQVVES TRPGKKVWLG ETSSAYGGGA PLLSDTFAAG FMWLDKLGLS ARMGIEVVMR QVFFGAGNYH LVDENFDPLP DYWLSLLFKK LVGTKVLMAS VQGSKRRKLR VYLHCTNTDN PRYKEGDLTL YAINLHNVTK YLRLPYPFSN KQVDKYLLRP LGPHGLLSKS VQLNGLTLKM VDDQTLPPLM EKPLRPGSSL GLPAFSYSFF VIRNAKVAAC I
Purity: >85 % by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 1.0 mg/ml (determined by Bradford assay)
Gene Name: HPSE heparanase [ Homo sapiens ]
Official Symbol: HPSE
Synonyms: HPSE; heparanase; HPA; HPSE1; HSE1; heparanase-1; endo-glucoronidase; HPA1; HPR1;
Gene ID: 10855
mRNA Refseq: NM_006665
Protein Refseq: NP_006656
MIM: 604724
UniProt ID: Q9Y251
Chromosome Location: 4q21.3
Pathway: Glycosaminoglycan degradation, organism-specific biosystem; Glycosaminoglycan degradation, conserved biosystem; Heparan sulfate degradation, organism-specific biosystem; Heparan sulfate degradation, conserved biosystem; Metabolic pathways, organism-specific biosystem; Syndecan-1-mediated signaling events, organism-specific biosystem;
Function: beta-glucuronidase activity; cation binding; hydrolase activity, acting on glycosyl bonds; protein binding; protein dimerization activity; syndecan binding;

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