"MGAT2" Related Products

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Recombinant Human MGAT2, His-tagged

Cat.No.: MGAT2-5118H
Product Overview: Recombinant human MGAT2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Description: MGAT2 is a golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. Transcript variants with a spliced 5" UTR may exist, but their biological validity has not been determined.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Molecular Mass: 50 kDa (439aa)
AA Sequence: MGSSHHHHHH SSGLVPRGSH MRQRKNEALA PPLLDAEPAR GAGGRGGDHP SVAVGIRRVS NVSAASLVPA VPQPEADNLT LRYRSLVYQL NFDQTLRNVD KAGTWAPREL VLVVQVHNRP EYLRLLLDSL RKAQGIDNVL VIFSHDFWST EINQLIAGVN FCPVLQVFFP FSIQLYPNEF PGSDPRDCPR DLPKNAALKL GCINAEYPDS FGHYREAKFS QTKHHWWWKL HFVWERVKIL RDYAGLILFL EEDHYLAPDF YHVFKKMWKL KQQECPECDV LSLGTYSASR SFYGMADKVD VKTWKSTEHN MGLALTRNAY QKLIECTDTF CTYDDYNWDW TLQYLTVSCL PKFWKVLVPQ IPRIFHAGDC GMHHKKTCRP STQSAQIESL LNNNKQYMFP ETLTISEKFT VVAISPPRKN GGWGDIRDHE LCKSYRRLQ
Purity: >85% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 1.0 mg/ml (determined by Bradford assay)
Gene Name: MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [ Homo sapiens (human) ]
Official Symbol: MGAT2
Synonyms: MGAT2;GNT2; CDG2A; CDGS2; GNT-II; GLCNACTII;alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;glcNAc-T II;mannoside acetylglucosaminyltransferase 2;Beta-1,2-N-acetylglucosaminyltransferase II;N-glycosyl-oligosaccharide-glycoprotein N-
Gene ID: 4247
mRNA Refseq: NM_002408.3
Protein Refseq: NP_002399.1
MIM: 602616
UniProt ID: Q10469
Chromosome Location: 14q21
Pathway: Asparagine N-linked glycosylation;Metabolism of proteins;N-Glycan biosynthesis;N-glycan antennae elongation in the medial/trans-Golgi;N-glycan biosynthesis, complex type
Function: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;carbohydrate binding

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