"IL4" Related Products

Recombinant Rhesus monkey IL4

Cat.No.: IL4-540R
Product Overview: Recombinant Rhesus monkey IL4 produced in E. coli is approximately 15.0 kDa, a single non-glycosylated polypeptide chain containing 129 amino acids.
Description: Interleukin-4 (IL-4) is a pleiotropic cytokine mainly produced by mast cells, activated T cells and bone marrow stromal cells. It has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4 + T-cells into Th2 cells. Additionally, It enhances both secretion and cell surface expression of IgE and IgG1 and also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. The rhesus macaque IL-4 shares about 40 % ~ 45 % a.a. sequence identity with human, mouse, rat IL-4 and they are species-specific in their activities.
Source: E. coli
Species: Rhesus monkey
Form: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, 3 % trehalose.
Bio-activity: Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using human TF-1 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0 × 10^6IU/mg.
Molecular Mass: 15 kDa
AA Sequence: HNCHIALREI IETLNSLTEQ KTLCTKLTIT DILAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE DFLERLKTIM REKYSKCSS
Endotoxin: Less than 1 EU/μg of rRhIL-4 as determined by LAL method.
Purity: >96% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apport
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportion
Gene Name: IL4 interleukin 4 [ Macaca mulatta (Rhesus monkey) ]
Official Symbol: IL4
Synonyms: IL4;interleukin-4;IL-4;BSF-1;B-cell stimulatory factor 1;lymphocyte stimulatory factor 1
Gene ID: 574281
mRNA Refseq: NM_001032904.1
Protein Refseq: NP_001028076.1
UniProt ID: P51492
Chromosome Location: chromosome: 6
Pathway: Allograft rejection;Asthma;Autoimmune thyroid disease;Cytokine-cytokine receptor interaction

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