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Recombinant Rat Osm protein

Cat.No. : Osm-585R
Product Overview : Recombinant Rat Osm protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
  • Related Products
Description : Oncostatin-M (OSM) is a multifunctional cytokine that belongs to the Interleukin-6 subfamily. Among the family members, OSM is most closely related to leukemia inhibitory factor (LIF) and it in fact utilizes the LIF receptor in addition to its specific receptor in the human. A biologically active OSM receptor has been previously described that consists of a heterodimer of leukemia inhibitory factor receptor (LIFR) and gp130. OSM is synthesized by stimulated T-cells and monocytes. Furthermore, the effects of OSM on endothelial cells suggest a pro-inflammatory role for OSM and endothelial cells possess a large number of OSM receptors. Recombinant murine OSM contains 215 amino acids and has a molecular mass of 22.4 kDa. It has approximately 48 % and 72 % amino acid sequence identity with human and murine OSM.
Source : E.coli
Species : Rat
Form : Lyophilized from a 0.2μm filtered concentrated solution in 2 × PBS, 0.1 % Tween-80.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine NIH-3T3 cells is less than 2.0 ng/ml, corresponding to a specific activity of > 5.0 × 10⁵ IU/mg.
Molecular Mass : Approximately 24.3 kDa, a single non-glycosylated polypeptide chain containing 214 amino acids.
Protein length : 214
AA Sequence : KRGCSSSSPKLLSQLKSQANITGNT ASLLEPYILHQNLNTLTLRAACTEH PVAFPSEDMLRQLSKPDFLSTVHAT LGRVWHQLGAFRQQFPKIQDFPELE RARQNIQGIRNNVYCMARLLHPPLE IPEPTQADSGTSRPTTTAPGIFQIK IDSCRFLWGYHRFMGSVGRVFEEWG DGSRRSRRHSPLWAWLKGDHRIRPS RSSQSAMLRSLVPR
Endotoxin : Less than 1 EU/μg of rRtOSM as determined by LAL method.
Purity : >96% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : Osm
Official Symbol : Osm
Synonyms : OSM; oncostatin M;
Gene ID : 114841
mRNA Refseq : NM_001006961.1
Protein Refseq : NP_001006962.1
UniProt ID : Q65Z15

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of OSM on cancer development and progression, particularly in terms of tumor microenvironment modulation? 03/25/2022

OSM can influence cancer progression by altering the tumor microenvironment and affecting tumor cell behavior.

How does OSM (Oncostatin M) regulate inflammatory and immune responses in the body? 01/30/2021

OSM plays a key role in regulating inflammatory and immune responses, modulating cytokine production and immune cell activity.

How does OSM contribute to wound healing and tissue regeneration processes? 06/08/2020

OSM aids in wound healing and tissue regeneration, promoting cell growth and repair mechanisms.

What role does OSM play in the pathogenesis of autoimmune diseases like rheumatoid arthritis? 04/27/2020

OSM is implicated in autoimmune diseases, contributing to inflammation and joint damage in conditions like rheumatoid arthritis.

How does OSM influence liver fibrosis and hepatic diseases? 03/17/2020

OSM is involved in liver fibrosis, impacting the development and progression of hepatic diseases.

What are the mechanisms by which OSM modulates cellular growth, differentiation, and apoptosis? 06/22/2018

OSM regulates cellular processes like growth, differentiation, and apoptosis, affecting various tissue functions.

How do alterations in OSM expression or signaling affect cardiovascular health and disease? 02/20/2018

Changes in OSM signaling can impact cardiovascular health, influencing disease development and progression.

Customer Reviews (3)

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Reviews
11/25/2020

    Outstanding protein-protein interaction studies, vital for our projects.

    03/02/2020

      High-quality protein characterization, fundamental for our experiments.

      02/27/2019

        Expertise in peptide synthesis, accelerates our peptide-based research.

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