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Recombinant Human RPS6KA3, GST-tagged

Cat.No.: RPS6KA3-154H
Product Overview: Recombinant full-length human RSK2 (L608F) mutant was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: RSK2 is a member of the RSK (ribosomal S6 kinase) family that consists of growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression. Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations.
Source: Sf9 insect cells using baculovirus
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: The specific activity of RSK2 (L608F) was determined to be 140 nmol /min/mg
Molecular Mass: ~112 kDa
Purity: >95% by densitometry
Applications: Kinase Assay, Western Blot
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 μg/μl
Gene Name: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [ Homo sapiens ]
Official Symbol: RPS6KA3
Synonyms: RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS, Coffin Lowry syndrome , mental retardation, X linked 19 , MRX19, ribosomal protein S6 kinase, 90kD, polypeptide 3; ribosomal protein S6 kinase alpha-3; HU 3; RSK; RSK2; RSK-2; p90-RSK 3; MAPKAPK-1b; S6K-alpha-3; MAPKAP kinase 1b; ribosomal S6 kinase 2; MAPK-activated protein kinase 1b; insulin-stimulated protein kinase 1; MAP kinase-activated protein kinase 1b; CLS; HU-3; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3;
Gene ID: 6197
mRNA Refseq: NM_004586
Protein Refseq: NP_004577
MIM: 300075
UniProt ID: P51812
Chromosome Location: Xp22.2-p22.1
Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Axon guidance, organism-specific biosystem; CREB phosphorylation, organism-specific biosystem; CREB phosphorylation through the activation of Ras, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Cytoplasmic Ribosomal Proteins, organism-specific biosystem;
Function: ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; magnesium ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity;

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