Recombinant Human UBE2C, His-tagged
Cat.No. : | UBE2C-221H |
Product Overview : | Recombinant full length human UBE2C was expressed in E. coli cells using an N-terminal His tag. |
- Specification
- Gene Information
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Description : | UBE2C or ubiquitin-conjugating enzyme E2C is a member of the E2 ubiquitin-conjugating enzyme family which is required for the destruction of mitotic cyclins and for cell cycle progression. UBE2C acted as a dominant-negative inhibitor which blocks the destruction of mitotic cyclins A and B and the onset of anaphase in frog embryos and mammalian cells. High UBE2C mRNA expression is associated with poor disease-free survival and overall survival. High tumor grade, as well as high Ki67 protein expression, was more frequent in the high-expression group of UBE2C. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~21 kDa |
Purity : | >95% by densitometry |
Applications : | Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | UBE2C ubiquitin-conjugating enzyme E2C [ Homo sapiens ] |
Official Symbol : | UBE2C |
Synonyms : | UBE2C; ubiquitin-conjugating enzyme E2C; ubiquitin-conjugating enzyme E2 C; UBCH10; ubiquitin-protein ligase C; ubiquitin carrier protein C; ubiquitin carrier protein E2-C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme; dJ447F3.2; |
Gene ID : | 11065 |
mRNA Refseq : | NM_007019 |
Protein Refseq : | NP_008950 |
MIM : | 605574 |
UniProt ID : | O00762 |
Chromosome Location : | 20q13.12 |
Pathway : | APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; |
Function : | ATP binding; acid-amino acid ligase activity; ligase activity; nucleotide binding; protein binding; ubiquitin-protein ligase activity; contributes_to ubiquitin-protein ligase activity; |
Products Types
◆ Recombinant Protein | ||
UBE2C-0029H | Recombinant Human UBE2C Protein (A2-P179), Tag Free | +Inquiry |
UBE2C-815C | Recombinant Cynomolgus Monkey UBE2C Protein, His (Fc)-Avi-tagged | +Inquiry |
UBE2C-0030H | Recombinant Human UBE2C Protein (A2-P179), His/Strep tagged | +Inquiry |
UBE2C-2295H | Recombinant Human UBE2C Protein, His (Fc)-Avi-tagged | +Inquiry |
Ube2c-6781M | Recombinant Mouse Ube2c Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
UBE2C-592HCL | Recombinant Human UBE2C 293 Cell Lysate | +Inquiry |
UBE2C-591HCL | Recombinant Human UBE2C 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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