Active Recombinant Human IL6, His-tagged
Cat.No. : | IL6-105H |
Product Overview : | Recombinant Human Interleukin-6/IL-6 is produced by E. coli transformed with a plasmid contains sequence (Pro29-Met212) of Human IL-6 fused with a polyhistidine tag at the C-terminus. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2 μM filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 5.0 |
Bio-activity : | Recombinant IL-6 is fully biologically active when compared to standards. ED50 is less than 0.1 ng/ml as determined by the dose-dependent stimulation of human TF-1 cells. Specific Activity of 5.0 x 10⁷ IU/mg. |
AA Sequence : | PVPPGEDSKDVAAPHRQPLTSSERI DKQIRYILDGISALRKETCNKSNMC ESSKEALAENNLNLP KMAEKDGCFQSGFNEETCLVKIITG LLEFEVYLEYLQNRFESSEEQARAV QMSTKVLIQFLQKKA KNLDAITTPDPTTNASLLTKLQAQN QWLQDMTTHLILRSFKEFLQSSLRA LRQM |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 98% as determined by RP-HPLC and reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Shipping : | The product is shipped at ambient temperature. |
Gene Name : | IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ] |
Official Symbol : | IL6 |
Synonyms : | IL6; interleukin 6 (interferon, beta 2); IFNB2; interleukin-6; BSF2; HGF; HSF; IL 6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor; IL-6; |
Gene ID : | 3569 |
mRNA Refseq : | NM_000600 |
Protein Refseq : | NP_000591 |
MIM : | 147620 |
UniProt ID : | P05231 |
Chromosome Location : | 7p21-p15 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Adipogenesis, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; |
Function : | cytokine activity; cytokine activity; growth factor activity; interleukin-6 receptor binding; contributes_to interleukin-6 receptor binding; interleukin-6 receptor binding; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.
The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.
Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.
Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.
This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.
The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.
Customer Reviews (3)
Write a reviewAccurate localization and function within the cell.
The binding affinity and affinity constant with the target are high.
Can form a stable micellar structure.
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