Recombinant Human TIRAP, His-tagged
Cat.No. : | TIRAP-116H |
Product Overview : | Recombinant human TIRAP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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Description : | The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol,2mM DTT |
Molecular Mass : | 26.3 kDa (244aa), confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSSLPPTHASDS GSSRWSKDYD VCVCHSEEDL VAAQDLVSYL EGSTASLRCF LQLRDATPGG AIVSELCQAL SSSHCRVLLI TPGFLQDPWC MASSTSL PAPGSRPKKP LGKMADWFRQ TLLKKPKKRP NSPESTSSDA SQPTSQDSPL PPSLSSVTSP KYQMLQALTE APGAEGCTIP LLSGLSRAAY PPELRFMYYV DGRGPDGGFR QVKEAVMRYL QTLS |
Purity : | > 90% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/ml (determined by Bradford assay) |
Gene Name : | TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein [ Homo sapiens (human) ] |
Official Symbol : | TIRAP |
Synonyms : | TIRAP; Mal; wyatt; BACTS1; MyD88-2; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; toll/interleukin-1 receptor domain-containing adapter protein; adapter protein wyatt; adaptor protein Wyatt; MyD88 adapter-like protein; Toll-like receptor adaptor protein |
Gene ID : | 114609 |
mRNA Refseq : | NM_001039661 |
Protein Refseq : | NP_001034750 |
MIM : | 606252 |
UniProt ID : | P58753 |
Chromosome Location : | 11q24.2 |
Pathway : | AGE/RAGE pathway; Hepatitis B; MyD88:Mal cascade initiated on plasma membrane |
Function : | Toll-like receptor 2 binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding, bridging |
Products Types
◆ Recombinant Protein | ||
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TIRAP-1117H | Recombinant Human TIRAP Protein, MYC/DDK-tagged | +Inquiry |
Tirap-595M | Recombinant Mouse Tirap Protein, MYC/DDK-tagged | +Inquiry |
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◆ Lysates | ||
TIRAP-1782HCL | Recombinant Human TIRAP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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