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Recombinant Mouse Chemokine (C-C motif) Ligand 20

Cat. No.: CCL20-50M
Product Overview: Recombinant Mouse Macrophage Inflammatory Protein-3 alpha produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.9 kDa. The MIP-3 is purified by proprietary chromatographic techniques.
Description: CCL-20 is a chemotactic factor that draws lymphocytes & neutrophils, rather than monocytes. MIP-3 alpha inhibits proliferation of myeloid progenitors in colony formation assays. MIP3A plays a role in the formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. CCL-20 holdes antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213. CCL-20 gene transcription is activated by H. pylori, which activates NF-kappaB through intracellular signal pathway which involves IkappaB kinase and NF-kappaB-inducing kinase. MIP-3 alpha is invloved in chemokine-mediated lymphocyte trafficking during gastric inflammation in Helicobacter infection. CCL-20 expression is involved in the recruitment of CD45R0-positive T cell subsets into the intestinal lamina propria. MIP-3A is in charge of the advancement of pulpal inflammation through the recruitment of C-C motif Receptor 6-expressing lymphocytes Vaginal epithelial cells respond to factors present in semen by secreting MIP-3 alpha, which increases langerhans cells recruitment during HIV transmission.
Source: Escherichia Coli.
Amino Acid Sequence: ASNYDCCLSY IQTPLPSRAI VGFTRQMADE ACDINAIIFH TKKRKSVCAD PKQNWVKRAV NLLSLRVKKM
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Solubility: It is recommended to reconstitute the lyophilized MIP-3a in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Specific Activity: The Activity is calculated by the ability to chemoattract Mouse CCR6 transfected HEK/293 cells at a concentration of 0.1-10 ng/ml.
Stability: Lyophilized MIP-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL-20 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: CCL20 chemokine (C-C motif) ligand 20 [ Homo sapiens ]
Synonyms: CCL20; chemokine (C-C motif) ligand 20; CKb4; LARC; MIP-3-alpha; MIP-3a; MIP-3[a]; MIP3A; SCYA20; ST38; exodus-1; Exodus-1; Beta chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; Small-inducible cytokine A20; Small inducible cytokine subfamily A (Cys-Cys), member 20; Small inducible cytokine A20 precursor; C-C motif chemokine 20; CC chemokine ST38; OTTMUSP00000017965; Small inducible cytokine subfamily A20
Gene ID: 6364
mRNA Refseq: NM_001130046
Protein Refseq: NP_001123518
MIM: 601960
UniProt ID: P78556
Chromosome Location: 2q33-q37
Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction
Function: chemokine activity

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